Reactome | IDO2 dioxygenates L-Trp to NFK

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IDO2 dioxygenates L-Trp to NFK Show undefined attributes

authored	[InstanceEdit:893590] D'Eustachio, P, 2010-07-01
catalystActivity	[CatalystActivity:888607] L-tryptophan 2,3-dioxygenase activity of IDO2 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643630] tryptophan 2,3-dioxygenase activity of IDO2 [cytosol] Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:888617] D'Eustachio, P, 2010-06-29
crossReference	[DatabaseIdentifier:12667989] RHEA:24537 [DatabaseIdentifier:9929636] RHEA:24537
dbId	888614
displayName	IDO2 dioxygenates L-Trp to NFK
edited	[InstanceEdit:893590] D'Eustachio, P, 2010-07-01
eventOf	[Pathway:R-HSA-71240] Tryptophan catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-71189] AFMID hydrolyses NFK to L-KYN - Homo sapiens
input	[SimpleEntity:R-ALL-29500] L-Trp [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:888609] Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	IDO2 dioxygenates L-Trp to NFK L-tryptophan + O2 => N-formyl-L-kynurenine tryptophan + O2 => N-formylkynurenine [IDO2]
orthologousEvent	[Reaction:R-SCE-888614] IDO2 dioxygenates L-Trp to NFK - Saccharomyces cerevisiae [Reaction:R-GGA-888614] IDO2 dioxygenates L-Trp to NFK - Gallus gallus [Reaction:R-XTR-888614] IDO2 dioxygenates L-Trp to NFK - Xenopus tropicalis [Reaction:R-DRE-888614] IDO2 dioxygenates L-Trp to NFK - Danio rerio [Reaction:R-SSC-888614] IDO2 dioxygenates L-Trp to NFK - Sus scrofa [Reaction:R-BTA-888614] IDO2 dioxygenates L-Trp to NFK - Bos taurus [Reaction:R-CFA-888614] IDO2 dioxygenates L-Trp to NFK - Canis familiaris [Reaction:R-RNO-888614] IDO2 dioxygenates L-Trp to NFK - Rattus norvegicus [Reaction:R-MMU-888614] IDO2 dioxygenates L-Trp to NFK - Mus musculus
output	[SimpleEntity:R-ALL-33179] NFK [cytosol]
precedingEvent	[Reaction:R-HSA-352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-8870352] SLC36A4 transports L-Trp from extracellular region to cytosol - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-888614
summation	[Summation:888610] Cytosolic indoleamine 2,3-dioxygenase 2 (IDO2) catalyzes the...
updateTrackers	[UpdateTracker:9939805] Update Tracker - [Reaction:888614] IDO2 dioxygenates L-Trp to NFK - v92:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9939805] Update Tracker - [Reaction:888614] IDO2 dioxygenates L-Trp to NFK - v92:[modifyText]
(hasEvent)	[Pathway:R-HSA-71240] Tryptophan catabolism
(precedingEvent)	[Reaction:R-HSA-71189] AFMID hydrolyses NFK to L-KYN

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