Reactome | kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O

Schema > Reaction > Entries

kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O Show undefined attributes

authored	[InstanceEdit:164915] D'Eustachio, P, 2005-07-20 13:46:37
catalystActivity	[CatalystActivity:71199] kynurenine 3-monooxygenase activity of KMO [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667987] RHEA:20546 [DatabaseIdentifier:9929645] RHEA:20546
dbId	71200
displayName	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O
edited	[InstanceEdit:164915] D'Eustachio, P, 2005-07-20 13:46:37
eventOf	[Pathway:R-HSA-71240] Tryptophan catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9972889] AADAT transaminates 3HKYN to xanthurenate - Homo sapiens [Reaction:R-HSA-71217] 3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+ - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29970] L-KYN [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:198585] Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase [LiteratureReference:9978937] On the submitochondrial localization of l-kynurenine-3-hydroxylase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O H(+) + L-kynurenine + NADPH + O2 => 3-hydroxy-L-kynurenine + H2O + NADP(+)
orthologousEvent	[Reaction:R-RNO-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Rattus norvegicus [Reaction:R-SCE-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Saccharomyces cerevisiae [Reaction:R-DDI-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Dictyostelium discoideum [Reaction:R-CEL-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Caenorhabditis elegans [Reaction:R-DME-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Drosophila melanogaster [Reaction:R-GGA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Gallus gallus [Reaction:R-XTR-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Xenopus tropicalis [Reaction:R-DRE-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Danio rerio [Reaction:R-SSC-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Sus scrofa [Reaction:R-BTA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Bos taurus [Reaction:R-CFA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Canis familiaris [Reaction:R-MMU-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Mus musculus
output	[SimpleEntity:R-ALL-34351] 3HKYN [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-71189] AFMID hydrolyses NFK to L-KYN - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71200
summation	[Summation:178923] Cytosolic kynurenine 3-monooxygenase (KMO) catalyzes the rea...
updateTrackers	[UpdateTracker:9792301] Update Tracker - [Reaction:71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - v22:[addLiteratureReference, modifyText] [UpdateTracker:9984682] Update Tracker - [Reaction:71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - v96:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9792301] Update Tracker - [Reaction:71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - v22:[addLiteratureReference, modifyText] [UpdateTracker:9984682] Update Tracker - [Reaction:71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - v96:[modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-71240] Tryptophan catabolism
(precedingEvent)	[Reaction:R-HSA-9972889] AADAT transaminates 3HKYN to xanthurenate [Reaction:R-HSA-71217] 3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+

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