Reactome | PXLP-KYAT1 dimer transaminates L-KYN to KYNA

Schema > Reaction > Entries

PXLP-KYAT1 dimer transaminates L-KYN to KYNA Show undefined attributes

authored	[InstanceEdit:893590] D'Eustachio, P, 2010-07-01
catalystActivity	[CatalystActivity:893577] kynurenine-oxoglutarate transaminase activity of PXLP-KYAT1 dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643870] kynurenine-oxoglutarate transaminase activity of PXLP-KYAT1 dimer [cytosol] Purification and characterization of kynurenine aminotransferase I from human brain
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:893590] D'Eustachio, P, 2010-07-01
crossReference	[DatabaseIdentifier:9929637] RHEA:65561 [DatabaseIdentifier:12667993] RHEA:65561
dbId	893596
deleted	[Deleted:9929658] Deletion of instance: 893609
displayName	PXLP-KYAT1 dimer transaminates L-KYN to KYNA
edited	[InstanceEdit:893590] D'Eustachio, P, 2010-07-01
eventOf	[Pathway:R-HSA-71240] Tryptophan catabolism - Homo sapiens
input	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [SimpleEntity:R-ALL-29970] L-KYN [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:893578] Purification and characterization of kynurenine aminotransferase I from human brain [LiteratureReference:893614] Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K [LiteratureReference:893612] The transamination of kynurenine [LiteratureReference:893582] Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase [LiteratureReference:893576] Crystal structure of human kynurenine aminotransferase I
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PXLP-KYAT1 dimer transaminates L-KYN to KYNA L-kynurenine + 2-oxoglutarate => kynurenate + L-glutamate + H2O
orthologousEvent	[Reaction:R-MMU-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Mus musculus [Reaction:R-CFA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Canis familiaris [Reaction:R-BTA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Bos taurus [Reaction:R-SSC-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Sus scrofa [Reaction:R-DRE-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Danio rerio [Reaction:R-XTR-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Xenopus tropicalis [Reaction:R-GGA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Gallus gallus [Reaction:R-DME-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Drosophila melanogaster [Reaction:R-CEL-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Caenorhabditis elegans [Reaction:R-DDI-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Dictyostelium discoideum [Reaction:R-SPO-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Schizosaccharomyces pombe [Reaction:R-SCE-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Saccharomyces cerevisiae [Reaction:R-RNO-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Rattus norvegicus [Reaction:R-HSA-901097] PXLP-KYAT3 (CCBL2) dimer transaminates L-KYN to KYNA - Homo sapiens
output	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-893587] KYNA [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
precedingEvent	[Reaction:R-HSA-71189] AFMID hydrolyses NFK to L-KYN - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[NegativeRegulation:R-HSA-2160520] Negative regulation by 'L-Phe [cytosol]' [NegativeRegulation:R-HSA-8939578] Negative regulation by 'I3LACT, I3PROPA [cytosol]'
regulationReference	[RegulationReference:9641942] Negative regulation by 'L-Phe [cytosol]' pH dependence, substrate specificity and inhibition of human kynurenine aminotransferase I [RegulationReference:9642714] Negative regulation by 'I3LACT, I3PROPA [cytosol]' Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1004534] Jassal, B, 2010-11-09 [InstanceEdit:9939375] Hill, David P, 2025-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-893596
summation	[Summation:893581] Kynurenine-oxoglutarate transaminase 1 (KYAT1, also known as...
updateTrackers	[UpdateTracker:9782156] Update Tracker - [Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu - v59:[addRegulator, modifyText] [UpdateTracker:9776017] Update Tracker - [Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu - v78:[modifyText] [UpdateTracker:9939792] Update Tracker - [Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - v92:[add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9788640] Update Tracker - [Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu - v41:[addRegulator]

Referrals

(hasEvent)	[Pathway:R-HSA-71240] Tryptophan catabolism
(replacementInstances)	[Deleted:9929658] Deletion of instance: 893609
(updatedInstance)	[UpdateTracker:9782156] Update Tracker - [Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu - v59:[addRegulator, modifyText] [UpdateTracker:9776017] Update Tracker - [Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu - v78:[modifyText] [UpdateTracker:9939792] Update Tracker - [Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - v92:[add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9788640] Update Tracker - [Reaction:893596] PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu - v41:[addRegulator]

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