Reactome | L-KYN [cytosol]

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L-KYN [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-HSA-901097] PXLP-KYAT3 (CCBL2) dimer transaminates L-KYN to KYNA - Homo sapiens [Reaction:R-SCE-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Saccharomyces cerevisiae [Reaction:R-SPO-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Schizosaccharomyces pombe [Reaction:R-DDI-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Dictyostelium discoideum [Reaction:R-CEL-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Caenorhabditis elegans [Reaction:R-DME-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Drosophila melanogaster [Reaction:R-GGA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Gallus gallus [Reaction:R-XTR-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Xenopus tropicalis [Reaction:R-DRE-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Danio rerio [Reaction:R-SSC-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Sus scrofa [Reaction:R-BTA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Bos taurus [Reaction:R-CFA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Canis familiaris [Reaction:R-MMU-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Mus musculus [Reaction:R-HSA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Homo sapiens [Reaction:R-RNO-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Rattus norvegicus [Reaction:R-SCE-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Saccharomyces cerevisiae [Reaction:R-DDI-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Dictyostelium discoideum [Reaction:R-CEL-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Caenorhabditis elegans [Reaction:R-DME-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Drosophila melanogaster [Reaction:R-GGA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Gallus gallus [Reaction:R-XTR-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Xenopus tropicalis [Reaction:R-DRE-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Danio rerio [Reaction:R-SSC-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Sus scrofa [Reaction:R-BTA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Bos taurus [Reaction:R-CFA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Canis familiaris [Reaction:R-MMU-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Mus musculus [Reaction:R-HSA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Homo sapiens [Reaction:R-RNO-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Rattus norvegicus [Reaction:R-HSA-9971629] Unknown NAT N-acetylates kynurenine - Homo sapiens
crossReference	[DatabaseIdentifier:29971] COMPOUND:C00328
dbId	29970
displayName	L-KYN [cytosol]
inDisease	false
maxDepth	1
modified	[InstanceEdit:9929640] D'Eustachio, Peter, 2024-11-27
name	L-KYN L-kynurenine zwitterion 3-Anthraniloyl-L-alanine L-kynurenine
producedByEvent	[Reaction:R-MMU-71196] N-formylkynurenine + H2O => kynurenine + formate [mouse] - Mus musculus [Reaction:R-HSA-71189] AFMID hydrolyses NFK to L-KYN - Homo sapiens
referenceEntity	[ReferenceMolecule:chebi:57959] L-kynurenine zwitterion [ChEBI:57959]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-29970
updateTrackers	[UpdateTracker:9890694] Update Tracker - [SimpleEntity:29970] L-KYN [cytosol] - v52:[modifyName] [UpdateTracker:9939988] Update Tracker - [SimpleEntity:29970] L-KYN [cytosol] - v92:[add_removeReferenceEntity, removeName] [UpdateTracker:9873468] Update Tracker - [SimpleEntity:29970] L-KYN [cytosol] - v43:[addName]

Referrals

(updatedInstance)	[UpdateTracker:9890694] Update Tracker - [SimpleEntity:29970] L-KYN [cytosol] - v52:[modifyName] [UpdateTracker:9939988] Update Tracker - [SimpleEntity:29970] L-KYN [cytosol] - v92:[add_removeReferenceEntity, removeName] [UpdateTracker:9873468] Update Tracker - [SimpleEntity:29970] L-KYN [cytosol] - v43:[addName]
(input)	[Reaction:R-HSA-9971629] Unknown NAT N-acetylates kynurenine [Reaction:R-HSA-901097] PXLP-KYAT3 (CCBL2) dimer transaminates L-KYN to KYNA [Reaction:R-SCE-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-SPO-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-DDI-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-CEL-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-DME-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-GGA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-XTR-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-DRE-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-SSC-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-BTA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-CFA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-MMU-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-HSA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-RNO-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA [Reaction:R-SCE-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O [Reaction:R-DDI-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O [Reaction:R-CEL-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O [Reaction:R-DME-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O [Reaction:R-GGA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O [Reaction:R-XTR-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O [Reaction:R-DRE-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O [Reaction:R-SSC-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O [Reaction:R-BTA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O [Reaction:R-CFA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O [Reaction:R-MMU-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O [Reaction:R-HSA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O [Reaction:R-RNO-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O
(output)	[Reaction:R-MMU-71196] N-formylkynurenine + H2O => kynurenine + formate [mouse] [Reaction:R-HSA-71189] AFMID hydrolyses NFK to L-KYN

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