AFMID hydrolyses NFK to L-KYN

Stable Identifier
R-HSA-71189
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
N-formylkynurenine + H2O => kynurenine + formate
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AFMID hydrolyses NFK to L-KYN
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Cytosolic arylformamidase (AFMID) catalyzes the hydrolysis of formylkynurenine to yield formate and L-kynurenine. Human AFMID has been identified only as an open reading frame; its activity is inferred from that of its well-characterized mouse homologue (Pabarcus and Casida 2002).

Literature References
PubMed ID Title Journal Year
12007602 Kynurenine formamidase: determination of primary structure and modeling-based prediction of tertiary structure and catalytic triad.

Pabarcus, MK, Casida, JE

Biochim Biophys Acta 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
arylformamidase activity of AFMID [cytosol]
Physical Entity
AFMID [cytosol]
Activity
arylformamidase activity (0004061)
Inferred From
N-formylkynurenine + H2O => kynurenine + formate [mouse] (Mus musculus)
Authored
D'Eustachio, P  (2005-07-20)