AFMID hydrolyses NFK to L-KYN

Stable Identifier
R-HSA-71189
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
N-formylkynurenine + H2O => kynurenine + formate
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
AFMID hydrolyses NFK to L-KYN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic arylformamidase (AFMID) catalyzes the hydrolysis of formylkynurenine to yield formate and L-kynurenine. Human AFMID has been identified only as an open reading frame; its activity is inferred from that of its well-characterized mouse homologue (Pabarcus and Casida 2002).

Literature References
PubMed ID Title Journal Year
12007602 Kynurenine formamidase: determination of primary structure and modeling-based prediction of tertiary structure and catalytic triad.

Casida, JE, Pabarcus, MK

Biochim Biophys Acta 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

arylformamidase activity of AFMID [cytosol]

Physical Entity
AFMID [cytosol] (Homo sapiens)
Activity
arylformamidase activity (GO:0004061)
Inferred From
N-formylkynurenine + H2O => kynurenine + formate [mouse] (Mus musculus)
Authored
D'Eustachio, P  (2005-07-20)
Cite Us!