Reactome | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A

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Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Show undefined attributes

authored	[InstanceEdit:69616] Hoffmann, I, Khanna, K, 2003-06-05 08:03:42
created	[InstanceEdit:69595] Hoffmann, I, 2003-06-05 08:03:42
dbId	69601
displayName	Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
eventOf	[Pathway:R-HSA-69613] p53-Independent G1/S DNA Damage Checkpoint - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-69604] Phosphorylation of CDC25A by CHEK1 - Homo sapiens [Reaction:R-HSA-69608] Phosphorylation of CDC25A by CHEK2 - Homo sapiens [BlackBoxEvent:R-HSA-9943678] CHEK1 phosphorylates CHEK2-phosphorylated CDC25A - Homo sapiens [Reaction:R-HSA-9942578] Phosphorylation of CDC25A by p38 MAPK - Homo sapiens [Reaction:R-HSA-9943687] PLK3 phosphorylates CDC25A - Homo sapiens [Reaction:R-HSA-9943675] GSK3B phosphorylates CDC25A - Homo sapiens [Reaction:R-HSA-9943662] CHEK1 phosphorylates NEK11 - Homo sapiens [Reaction:R-HSA-9943676] NEK11 phosphorylates CDC25A - Homo sapiens [Reaction:R-HSA-9943736] Casein kinase I phosphorylates CDC25A - Homo sapiens [Reaction:R-HSA-69598] Ubiquitination of phosphorylated CDC25A - Homo sapiens [BlackBoxEvent:R-HSA-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:212978] Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation [LiteratureReference:69264] Rapid destruction of human Cdc25A in response to DNA damage. [LiteratureReference:9941771] Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis [LiteratureReference:9941784] The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis [LiteratureReference:9941775] Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage [LiteratureReference:9941822] SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase [LiteratureReference:9942580] Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint [LiteratureReference:9943677] GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers [LiteratureReference:9943993] Mammalian G1- and S-phase checkpoints in response to DNA damage [LiteratureReference:9943654] NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint [LiteratureReference:9943731] Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction [LiteratureReference:9943730] CK1? targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation [LiteratureReference:9944016] Ubiquitin ligases and cell cycle control
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
orthologousEvent	[Pathway:R-DDI-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Dictyostelium discoideum [Pathway:R-MMU-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Mus musculus [Pathway:R-RNO-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Rattus norvegicus [Pathway:R-CFA-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Canis familiaris [Pathway:R-BTA-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Bos taurus [Pathway:R-SSC-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Sus scrofa [Pathway:R-DRE-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Danio rerio [Pathway:R-XTR-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Xenopus tropicalis [Pathway:R-GGA-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Gallus gallus [Pathway:R-DME-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Drosophila melanogaster [Pathway:R-CEL-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Caenorhabditis elegans [Pathway:R-SPO-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Schizosaccharomyces pombe [Pathway:R-SCE-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Saccharomyces cerevisiae
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:69616] Hoffmann, I, Khanna, K, 2003-06-05 08:03:42
revised	[InstanceEdit:9943824] Orlic-Milacic, Marija, 2025-03-31
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-69601
summation	[Summation:212961] CDC25A protein, a phosphatase required for progression fr...
updateTrackers	[UpdateTracker:9953664] Update Tracker - [Pathway:69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - v93:[modifyText, removeLiteratureReference] [UpdateTracker:9792058] Update Tracker - [Pathway:69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - v24:[addSummation] [UpdateTracker:9790775] Update Tracker - [Pathway:69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - v33:[addHasEvent] [UpdateTracker:9778290] Update Tracker - [Pathway:69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - v68:[removeHasEvent] [UpdateTracker:9781317] Update Tracker - [Pathway:69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - v61:[updateContainedRLE] [UpdateTracker:9784281] Update Tracker - [Pathway:69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - v54:[updateContainedRLE] [UpdateTracker:9789315] Update Tracker - [Pathway:69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - v38:[addLiteratureReference] [UpdateTracker:9782060] Update Tracker - [Pathway:69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - v59:[updateContainedRLE] [UpdateTracker:9964699] Update Tracker - [Pathway:69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - v94:[removeHasEvent]

Referrals

(hasEvent)

[Pathway:R-HSA-69613] p53-Independent G1/S DNA Damage Checkpoint

(updatedInstance)

[UpdateTracker:9953664] Update Tracker - [Pathway:69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - v93:[modifyText, removeLiteratureReference]
[UpdateTracker:9792058] Update Tracker - [Pathway:69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - v24:[addSummation]
[UpdateTracker:9790775] Update Tracker - [Pathway:69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - v33:[addHasEvent]
[UpdateTracker:9778290] Update Tracker - [Pathway:69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - v68:[removeHasEvent]
[UpdateTracker:9781317] Update Tracker - [Pathway:69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - v61:[updateContainedRLE]
[UpdateTracker:9784281] Update Tracker - [Pathway:69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - v54:[updateContainedRLE]
[UpdateTracker:9789315] Update Tracker - [Pathway:69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - v38:[addLiteratureReference]
[UpdateTracker:9782060] Update Tracker - [Pathway:69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - v59:[updateContainedRLE]
[UpdateTracker:9964699] Update Tracker - [Pathway:69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - v94:[removeHasEvent]

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