Reactome | Phosphorylation of CDC25A by CHEK1

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Phosphorylation of CDC25A by CHEK1 Show undefined attributes

authored	[InstanceEdit:69616] Hoffmann, I, Khanna, K, 2003-06-05 08:03:42
catalystActivity	[CatalystActivity:143490] protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:69595] Hoffmann, I, 2003-06-05 08:03:42
dbId	69604
deleted	[Deleted:8986069] Deletion of instance: 69591
displayName	Phosphorylation of CDC25A by CHEK1
eventOf	[Pathway:R-HSA-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Homo sapiens [Pathway:R-HSA-176187] Activation of ATR in response to replication stress - Homo sapiens
followingEvent	[Reaction:R-HSA-9943736] Casein kinase I phosphorylates CDC25A - Homo sapiens [Reaction:R-HSA-9943676] NEK11 phosphorylates CDC25A - Homo sapiens
input	5 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-143487] CDC25A [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:69451] Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. [LiteratureReference:9941611] Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 [LiteratureReference:69264] Rapid destruction of human Cdc25A in response to DNA damage. [LiteratureReference:9941775] Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage [LiteratureReference:9941805] Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A [LiteratureReference:9941816] Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents [LiteratureReference:9942580] Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint [LiteratureReference:9942592] Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint [LiteratureReference:9943649] Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Phosphorylation of CDC25A by CHEK1
orthologousEvent	[Reaction:R-SCE-69604] Phosphorylation of CDC25A by CHEK1 - Saccharomyces cerevisiae [Reaction:R-SPO-69604] Phosphorylation of CDC25A by CHEK1 - Schizosaccharomyces pombe [Reaction:R-DDI-69604] Phosphorylation of CDC25A by CHEK1 - Dictyostelium discoideum [Reaction:R-CEL-69604] Phosphorylation of CDC25A by CHEK1 - Caenorhabditis elegans [Reaction:R-DME-69604] Phosphorylation of CDC25A by CHEK1 - Drosophila melanogaster [Reaction:R-GGA-69604] Phosphorylation of CDC25A by CHEK1 - Gallus gallus [Reaction:R-SSC-69604] Phosphorylation of CDC25A by CHEK1 - Sus scrofa [Reaction:R-CFA-69604] Phosphorylation of CDC25A by CHEK1 - Canis familiaris [Reaction:R-RNO-69604] Phosphorylation of CDC25A by CHEK1 - Rattus norvegicus [Reaction:R-MMU-69604] Phosphorylation of CDC25A by CHEK1 - Mus musculus
output	5 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-143488] p-S76,S124,S178,S279,S293-CDC25A [nucleoplasm]
precedingEvent	[Reaction:R-HSA-176116] Recruitment and activation of Chk1 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:69616] Hoffmann, I, Khanna, K, 2003-06-05 08:03:42
revised	[InstanceEdit:9943824] Orlic-Milacic, Marija, 2025-03-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-69604
summation	[Summation:69605] DNA damage caused by ultraviolet light (UV), ionizing rad...
updateTrackers	[UpdateTracker:9953655] Update Tracker - [Reaction:69604] Phosphorylation of CDC25A by CHEK1 - v93:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9953655] Update Tracker - [Reaction:69604] Phosphorylation of CDC25A by CHEK1 - v93:[modifyText, removeLiteratureReference]
(replacementInstances)	[Deleted:8986069] Deletion of instance: 69591
(hasEvent)	[Pathway:R-HSA-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A [Pathway:R-HSA-176187] Activation of ATR in response to replication stress
(precedingEvent)	[Reaction:R-HSA-9943736] Casein kinase I phosphorylates CDC25A [Reaction:R-HSA-9943676] NEK11 phosphorylates CDC25A

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