Reactome | p53-Independent G1/S DNA Damage Checkpoint

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p53-Independent G1/S DNA Damage Checkpoint Show undefined attributes

authored	[InstanceEdit:69616] Hoffmann, I, Khanna, K, 2003-06-05 08:03:42
created	[InstanceEdit:69595] Hoffmann, I, 2003-06-05 08:03:42
dbId	69613
deleted	[Deleted:9953052] Deletion of instance: 69610
displayName	p53-Independent G1/S DNA Damage Checkpoint
eventOf	[Pathway:R-HSA-69615] G1/S DNA Damage Checkpoints - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-HSA-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:69264] Rapid destruction of human Cdc25A in response to DNA damage. [LiteratureReference:9943993] Mammalian G1- and S-phase checkpoints in response to DNA damage [LiteratureReference:9944002] CDC25A: a rebel within the CDC25 phosphatases family? [LiteratureReference:9941784] The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis [LiteratureReference:9944000] Cell cycle control, checkpoint mechanisms, and genotoxic stress [LiteratureReference:9944016] Ubiquitin ligases and cell cycle control
maxDepth	3
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	p53-Independent G1/S DNA Damage Checkpoint
orthologousEvent	[Pathway:R-DDI-69613] p53-Independent G1/S DNA Damage Checkpoint - Dictyostelium discoideum [Pathway:R-SCE-69613] p53-Independent G1/S DNA Damage Checkpoint - Saccharomyces cerevisiae [Pathway:R-SPO-69613] p53-Independent G1/S DNA Damage Checkpoint - Schizosaccharomyces pombe [Pathway:R-CEL-69613] p53-Independent G1/S DNA Damage Checkpoint - Caenorhabditis elegans [Pathway:R-DME-69613] p53-Independent G1/S DNA Damage Checkpoint - Drosophila melanogaster [Pathway:R-GGA-69613] p53-Independent G1/S DNA Damage Checkpoint - Gallus gallus [Pathway:R-XTR-69613] p53-Independent G1/S DNA Damage Checkpoint - Xenopus tropicalis [Pathway:R-DRE-69613] p53-Independent G1/S DNA Damage Checkpoint - Danio rerio [Pathway:R-SSC-69613] p53-Independent G1/S DNA Damage Checkpoint - Sus scrofa [Pathway:R-BTA-69613] p53-Independent G1/S DNA Damage Checkpoint - Bos taurus [Pathway:R-CFA-69613] p53-Independent G1/S DNA Damage Checkpoint - Canis familiaris [Pathway:R-RNO-69613] p53-Independent G1/S DNA Damage Checkpoint - Rattus norvegicus [Pathway:R-MMU-69613] p53-Independent G1/S DNA Damage Checkpoint - Mus musculus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:69616] Hoffmann, I, Khanna, K, 2003-06-05 08:03:42
revised	[InstanceEdit:9943824] Orlic-Milacic, Marija, 2025-03-31
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-69613
summation	[Summation:69614] The G1/S arrest induced by DNA damage has been ascribed t...
updateTrackers	[UpdateTracker:9789442] Update Tracker - [Pathway:69613] p53-Independent G1/S DNA damage checkpoint - v38:[updateContainedPathway] [UpdateTracker:9791154] Update Tracker - [Pathway:69613] p53-Independent G1/S DNA damage checkpoint - v32:[removeHasEvent] [UpdateTracker:9778115] Update Tracker - [Pathway:69613] p53-Independent G1/S DNA damage checkpoint - v68:[updateContainedPathway] [UpdateTracker:9792061] Update Tracker - [Pathway:69613] p53-Independent G1/S DNA damage checkpoint - v24:[updateContainedPathway] [UpdateTracker:9790532] Update Tracker - [Pathway:69613] p53-Independent G1/S DNA damage checkpoint - v33:[updateContainedPathway] [UpdateTracker:9781422] Update Tracker - [Pathway:69613] p53-Independent G1/S DNA damage checkpoint - v61:[updateContainedPathway] [UpdateTracker:9953702] Update Tracker - [Pathway:69613] p53-Independent G1/S DNA Damage Checkpoint - v93:[add_removeHasEvent, modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9789442] Update Tracker - [Pathway:69613] p53-Independent G1/S DNA damage checkpoint - v38:[updateContainedPathway] [UpdateTracker:9791154] Update Tracker - [Pathway:69613] p53-Independent G1/S DNA damage checkpoint - v32:[removeHasEvent] [UpdateTracker:9778115] Update Tracker - [Pathway:69613] p53-Independent G1/S DNA damage checkpoint - v68:[updateContainedPathway] [UpdateTracker:9792061] Update Tracker - [Pathway:69613] p53-Independent G1/S DNA damage checkpoint - v24:[updateContainedPathway] [UpdateTracker:9790532] Update Tracker - [Pathway:69613] p53-Independent G1/S DNA damage checkpoint - v33:[updateContainedPathway] [UpdateTracker:9781422] Update Tracker - [Pathway:69613] p53-Independent G1/S DNA damage checkpoint - v61:[updateContainedPathway] [UpdateTracker:9953702] Update Tracker - [Pathway:69613] p53-Independent G1/S DNA Damage Checkpoint - v93:[add_removeHasEvent, modifyText, removeLiteratureReference]
(replacementInstances)	[Deleted:9953052] Deletion of instance: 69610
(hasEvent)	[Pathway:R-HSA-69615] G1/S DNA Damage Checkpoints

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