Reactome | Phosphorylation of Cdc25A at Ser-123 by Chk2

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Phosphorylation of Cdc25A at Ser-123 by Chk2 Show undefined attributes

catalystActivity	[CatalystActivity:5683804] protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:69595] Hoffmann, I, 2003-06-05 08:03:42
dbId	69608
displayName	Phosphorylation of Cdc25A at Ser-123 by Chk2
eventOf	[Pathway:R-HSA-69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-143487] CDC25A [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:69611] The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	Phosphorylation of Cdc25A at Ser-123 by Chk2
orthologousEvent	[Reaction:R-MMU-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Mus musculus [Reaction:R-SCE-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Saccharomyces cerevisiae [Reaction:R-SPO-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Schizosaccharomyces pombe [Reaction:R-DDI-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Dictyostelium discoideum [Reaction:R-CEL-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Caenorhabditis elegans [Reaction:R-DME-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Drosophila melanogaster [Reaction:R-GGA-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Gallus gallus [Reaction:R-XTR-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Xenopus tropicalis [Reaction:R-SSC-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Sus scrofa [Reaction:R-BTA-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Bos taurus [Reaction:R-CFA-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Canis familiaris [Reaction:R-RNO-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Rattus norvegicus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-143488] p-S124-CDC25A [nucleoplasm]
precedingEvent	[Reaction:R-HSA-69891] Phosphorylation and activation of CHEK2 by ATM - Homo sapiens [Reaction:R-HSA-5683792] p-T68-CHEK2 autophosphorylates - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-69608
summation	[Summation:69609] Detection of DNA damage caused by ionizing radiation results...

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(hasEvent)

[Pathway:R-HSA-69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A