Reactome | NEK11 phosphorylates CDC25A

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NEK11 phosphorylates CDC25A Show undefined attributes

authored	[InstanceEdit:9943824] Orlic-Milacic, Marija, 2025-03-31
catalystActivity	[CatalystActivity:9943709] protein serine/threonine kinase activity of p-S273-NEK11 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9943674] Orlic-Milacic, Marija, 2025-03-31
dbId	9943676
displayName	NEK11 phosphorylates CDC25A
edited	[InstanceEdit:9963937] Orlic-Milacic, Marija, 2025-08-18
eventOf	[Pathway:R-HSA-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Homo sapiens
followingEvent	[Reaction:R-HSA-69598] Ubiquitination of phosphorylated CDC25A - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [CandidateSet:R-HSA-9943713] p-S76-CDC25A [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9943654] NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	NEK11 phosphorylates CDC25A
orthologousEvent	[Reaction:R-DDI-9943676] NEK11 phosphorylates CDC25A - Dictyostelium discoideum [Reaction:R-DRE-9943676] NEK11 phosphorylates CDC25A - Danio rerio [Reaction:R-SSC-9943676] NEK11 phosphorylates CDC25A - Sus scrofa [Reaction:R-BTA-9943676] NEK11 phosphorylates CDC25A - Bos taurus [Reaction:R-MMU-9943676] NEK11 phosphorylates CDC25A - Mus musculus
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [CandidateSet:R-HSA-9943706] p-S76,S79,S82,S88-CDC25A [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9943678] CHEK1 phosphorylates CHEK2-phosphorylated CDC25A - Homo sapiens [Reaction:R-HSA-9943662] CHEK1 phosphorylates NEK11 - Homo sapiens [Reaction:R-HSA-9943675] GSK3B phosphorylates CDC25A - Homo sapiens [Reaction:R-HSA-69604] Phosphorylation of CDC25A by CHEK1 - Homo sapiens [Reaction:R-HSA-9942578] Phosphorylation of CDC25A by p38 MAPK - Homo sapiens
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9943676
summation	[Summation:9943720] NEK11, isolated as one of the genes whose knockdown overr...

Referrals

(hasEvent)	[Pathway:R-HSA-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
(precedingEvent)	[Reaction:R-HSA-69598] Ubiquitination of phosphorylated CDC25A