Reactome | Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A

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Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Show undefined attributes

created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11048906
displayName	Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
eventOf	[Pathway:R-DDI-69613] p53-Independent G1/S DNA Damage Checkpoint - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DDI-69604] Phosphorylation of CDC25A by CHEK1 - Dictyostelium discoideum [Reaction:R-DDI-69608] Phosphorylation of CDC25A by CHEK2 - Dictyostelium discoideum [BlackBoxEvent:R-DDI-9943678] CHEK1 phosphorylates CHEK2-phosphorylated CDC25A - Dictyostelium discoideum [Reaction:R-DDI-9942578] Phosphorylation of CDC25A by p38 MAPK - Dictyostelium discoideum [Reaction:R-DDI-9943687] PLK3 phosphorylates CDC25A - Dictyostelium discoideum [Reaction:R-DDI-9943675] GSK3B phosphorylates CDC25A - Dictyostelium discoideum [Reaction:R-DDI-9943662] CHEK1 phosphorylates NEK11 - Dictyostelium discoideum [Reaction:R-DDI-9943676] NEK11 phosphorylates CDC25A - Dictyostelium discoideum [Reaction:R-DDI-9943736] Casein kinase I phosphorylates CDC25A - Dictyostelium discoideum [Reaction:R-DDI-69598] Ubiquitination of phosphorylated CDC25A - Dictyostelium discoideum [BlackBoxEvent:R-DDI-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-69601
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-69613] p53-Independent G1/S DNA Damage Checkpoint
(inferredTo)	[Pathway:R-HSA-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A

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