Reactome | Proteolytic degradation of ubiquitinated-Cdc25A

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Proteolytic degradation of ubiquitinated-Cdc25A Show undefined attributes

authored	[InstanceEdit:69616] Hoffmann, I, Khanna, K, 2003-06-05 08:03:42
catalystActivity	[CatalystActivity:174087] endopeptidase activity of 26S proteasome [nucleoplasm]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:69595] Hoffmann, I, 2003-06-05 08:03:42
dbId	69600
displayName	Proteolytic degradation of ubiquitinated-Cdc25A
eventOf	[Pathway:R-HSA-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A - Homo sapiens
input	[DefinedSet:R-HSA-9943733] PolyUb-p-S82-CDC25A [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:69264] Rapid destruction of human Cdc25A in response to DNA damage. [LiteratureReference:9941775] Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage [LiteratureReference:9941816] Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents [LiteratureReference:9943730] CK1? targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Proteolytic degradation of ubiquitinated-Cdc25A
orthologousEvent	[BlackBoxEvent:R-DDI-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Dictyostelium discoideum [BlackBoxEvent:R-CEL-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Caenorhabditis elegans [BlackBoxEvent:R-DME-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Drosophila melanogaster [BlackBoxEvent:R-GGA-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Gallus gallus [BlackBoxEvent:R-XTR-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Xenopus tropicalis [BlackBoxEvent:R-DRE-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Danio rerio [BlackBoxEvent:R-SSC-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Sus scrofa [BlackBoxEvent:R-BTA-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Bos taurus [BlackBoxEvent:R-CFA-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Canis familiaris [BlackBoxEvent:R-RNO-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Rattus norvegicus [BlackBoxEvent:R-MMU-69600] Proteolytic degradation of ubiquitinated-Cdc25A - Mus musculus
output	3 × [DefinedSet:R-HSA-68524] Ub [nucleoplasm]
precedingEvent	[Reaction:R-HSA-69598] Ubiquitination of phosphorylated CDC25A - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821385] four stars
reviewed	[InstanceEdit:69616] Hoffmann, I, Khanna, K, 2003-06-05 08:03:42
revised	[InstanceEdit:9943824] Orlic-Milacic, Marija, 2025-03-31
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-69600
summation	[Summation:179124] Exposure of various human cell lines to ultraviolet (UV) ...
updateTrackers	[UpdateTracker:9782460] Update Tracker - [BlackBoxEvent:69600] Proteolytic degradation of ubiquitinated-Cdc25A - v59:[add_removeOutput] [UpdateTracker:9780909] Update Tracker - [BlackBoxEvent:69600] Proteolytic degradation of ubiquitinated-Cdc25A - v61:[addLiteratureReference, modifyText] [UpdateTracker:9953720] Update Tracker - [BlackBoxEvent:69600] Proteolytic degradation of ubiquitinated-Cdc25A - v93:[add_removeCatalystActivity, add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782460] Update Tracker - [BlackBoxEvent:69600] Proteolytic degradation of ubiquitinated-Cdc25A - v59:[add_removeOutput] [UpdateTracker:9780909] Update Tracker - [BlackBoxEvent:69600] Proteolytic degradation of ubiquitinated-Cdc25A - v61:[addLiteratureReference, modifyText] [UpdateTracker:9953720] Update Tracker - [BlackBoxEvent:69600] Proteolytic degradation of ubiquitinated-Cdc25A - v93:[add_removeCatalystActivity, add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-69601] Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
(precedingEvent)	[NegativePrecedingEvent:9944349] Proteolytic degradation of ubiquitinated-Cdc25A [NegativePrecedingEvent:9944350] Abundant Molecules: Proteolytic degradation of ubiquitinated-Cdc25A [NegativePrecedingEvent:9749043] Incorrect Order: Proteolytic degradation of ubiquitinated-Cdc25A [NegativePrecedingEvent:9749038] Abundant Molecules: Proteolytic degradation of ubiquitinated-Cdc25A

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