Reactome | COPI-mediated anterograde transport

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COPI-mediated anterograde transport Show undefined attributes

authored	[InstanceEdit:6793574] Rothfels, Karen, 2015-09-01
created	[InstanceEdit:6807879] Rothfels, Karen, 2015-11-03
dbId	6807878
displayName	COPI-mediated anterograde transport
edited	[InstanceEdit:6793574] Rothfels, Karen, 2015-09-01
eventOf	[Pathway:R-HSA-199977] ER to Golgi Anterograde Transport - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-6807864] RAB1:GTP recruits GBF1 to the ERGIC - Homo sapiens [Reaction:R-HSA-6807866] GBF1 recruits ARF:GDP to the ERGIC - Homo sapiens [Reaction:R-HSA-6807868] GBF1 stimulates ARF nucleotide exchange - Homo sapiens [Reaction:R-HSA-6807872] Active ARF recruits coatomer - Homo sapiens [Reaction:R-HSA-6807875] ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex - Homo sapiens [Reaction:R-HSA-6807877] ARFGAPs stimulate ARF GTPase activity - Homo sapiens [Reaction:R-HSA-6809003] ERGIC-to-Golgi vesicles bind dynein:dynactin - Homo sapiens [Reaction:R-HSA-6809006] Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex - Homo sapiens [Reaction:R-HSA-6809011] cis-Golgi t-SNAREs bind YKT6 on tethered vesicle - Homo sapiens [BlackBoxEvent:R-HSA-6809010] COPI vesicle uncoating - Homo sapiens [Reaction:R-HSA-6809014] cis-Golgi cis-SNARE binds NSF and SNAPs - Homo sapiens [BlackBoxEvent:R-HSA-6809015] NSF ATPase activity dissociates cis-SNARE at cis-Golgi - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6804917] Live imaging of bidirectional traffic from the ERGIC [LiteratureReference:5688472] COPII and COPI traffic at the ER-Golgi interface [LiteratureReference:6804891] Beta-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivo [LiteratureReference:6804910] ER-to-Golgi transport visualized in living cells [LiteratureReference:6804928] Visualization of ER-to-Golgi transport in living cells reveals a sequential mode of action for COPII and COPI [LiteratureReference:204031] COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites [LiteratureReference:5685808] The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi [LiteratureReference:6804927] Retrograde traffic from the Golgi to the endoplasmic reticulum
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	COPI-mediated anterograde transport
orthologousEvent	[Pathway:R-BTA-6807878] COPI-mediated anterograde transport - Bos taurus [Pathway:R-PFA-6807878] COPI-mediated anterograde transport - Plasmodium falciparum [Pathway:R-SCE-6807878] COPI-mediated anterograde transport - Saccharomyces cerevisiae [Pathway:R-SPO-6807878] COPI-mediated anterograde transport - Schizosaccharomyces pombe [Pathway:R-DDI-6807878] COPI-mediated anterograde transport - Dictyostelium discoideum [Pathway:R-CEL-6807878] COPI-mediated anterograde transport - Caenorhabditis elegans [Pathway:R-DME-6807878] COPI-mediated anterograde transport - Drosophila melanogaster [Pathway:R-GGA-6807878] COPI-mediated anterograde transport - Gallus gallus [Pathway:R-XTR-6807878] COPI-mediated anterograde transport - Xenopus tropicalis [Pathway:R-DRE-6807878] COPI-mediated anterograde transport - Danio rerio [Pathway:R-SSC-6807878] COPI-mediated anterograde transport - Sus scrofa [Pathway:R-CFA-6807878] COPI-mediated anterograde transport - Canis familiaris [Pathway:R-RNO-6807878] COPI-mediated anterograde transport - Rattus norvegicus [Pathway:R-MMU-6807878] COPI-mediated anterograde transport - Mus musculus
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793638] Gillespie, Marc E, 2015-09-02
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6807878
summation	[Summation:6807729] The ERGIC (ER-to-Golgi intermediate compartment, also known ...

Referrals

(hasEvent)

[Pathway:R-HSA-199977] ER to Golgi Anterograde Transport

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