Reactome | GBF1 recruits ARF:GDP to the ERGIC

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GBF1 recruits ARF:GDP to the ERGIC Show undefined attributes

authored	[InstanceEdit:6793574] Rothfels, Karen, 2015-09-01
category	binding
compartment	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created	[InstanceEdit:6807867] Rothfels, Karen, 2015-11-03
dbId	6807866
displayName	GBF1 recruits ARF:GDP to the ERGIC
edited	[InstanceEdit:6793574] Rothfels, Karen, 2015-09-01
eventOf	[Pathway:R-HSA-6807878] COPI-mediated anterograde transport - Homo sapiens
followingEvent	[Reaction:R-HSA-6807868] GBF1 stimulates ARF nucleotide exchange - Homo sapiens
input	[Complex:R-HSA-6807786] ARF:GDP [cytosol] [Complex:R-HSA-6807800] RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6804924] Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association [LiteratureReference:6804905] Characterization of class I and II ADP-ribosylation factors (Arfs) in live cells: GDP-bound class II Arfs associate with the ER-Golgi intermediate compartment independently of GBF1 [LiteratureReference:6804887] ARF proteins: roles in membrane traffic and beyond [LiteratureReference:5688472] COPII and COPI traffic at the ER-Golgi interface [LiteratureReference:6805308] Arf3 is activated uniquely at the trans-Golgi network by brefeldin A-inhibited guanine nucleotide exchange factors [LiteratureReference:6804916] Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic [LiteratureReference:6807698] Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23 [LiteratureReference:6807668] Diverse roles for the p24 family of proteins in eukaryotic cells
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	GBF1 recruits ARF:GDP to the ERGIC
orthologousEvent	[Reaction:R-SCE-6807866] GBF1 recruits ARF:GDP to the ERGIC - Saccharomyces cerevisiae [Reaction:R-SPO-6807866] GBF1 recruits ARF:GDP to the ERGIC - Schizosaccharomyces pombe [Reaction:R-DDI-6807866] GBF1 recruits ARF:GDP to the ERGIC - Dictyostelium discoideum [Reaction:R-CEL-6807866] GBF1 recruits ARF:GDP to the ERGIC - Caenorhabditis elegans [Reaction:R-DME-6807866] GBF1 recruits ARF:GDP to the ERGIC - Drosophila melanogaster [Reaction:R-DRE-6807866] GBF1 recruits ARF:GDP to the ERGIC - Danio rerio [Reaction:R-BTA-6807866] GBF1 recruits ARF:GDP to the ERGIC - Bos taurus [Reaction:R-CFA-6807866] GBF1 recruits ARF:GDP to the ERGIC - Canis familiaris [Reaction:R-RNO-6807866] GBF1 recruits ARF:GDP to the ERGIC - Rattus norvegicus [Reaction:R-MMU-6807866] GBF1 recruits ARF:GDP to the ERGIC - Mus musculus
output	[Complex:R-HSA-6807803] RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane]
precedingEvent	[Reaction:R-HSA-6807864] RAB1:GTP recruits GBF1 to the ERGIC - Homo sapiens
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793638] Gillespie, Marc E, 2015-09-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6807866
summation	[Summation:6807722] GBF1 recruits inactive ARF:GDP complexes to the ERGIC (Monet...

Referrals

(hasEvent)	[Pathway:R-HSA-6807878] COPI-mediated anterograde transport
(precedingEvent)	[Reaction:R-HSA-6807868] GBF1 stimulates ARF nucleotide exchange

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