Reactome | NSF ATPase activity dissociates cis-SNARE at cis-Golgi

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NSF ATPase activity dissociates cis-SNARE at cis-Golgi Show undefined attributes

authored	[InstanceEdit:6807636] Rothfels, Karen, 2015-11-03
catalystActivity	[CatalystActivity:6809005] ATP hydrolysis activity of cis-SNARE:3xSNAP:NSF hexamer [Golgi membrane]
category	uncertain
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:6809013] Rothfels, Karen, 2015-11-09
dbId	6809015
displayName	NSF ATPase activity dissociates cis-SNARE at cis-Golgi
edited	[InstanceEdit:6807636] Rothfels, Karen, 2015-11-03
eventOf	[Pathway:R-HSA-6807878] COPI-mediated anterograde transport - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-6808999] cis-SNARE:3xSNAP:NSF hexamer [Golgi membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5688473] Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles [LiteratureReference:5688485] An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion [LiteratureReference:5688502] Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion [LiteratureReference:5688488] Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles [LiteratureReference:5688492] Multiple binding proteins suggest diverse functions for the N-ethylmaleimide sensitive factor [LiteratureReference:5688493] NSF N-terminal domain crystal structure: models of NSF function [LiteratureReference:5688498] Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF) [LiteratureReference:5688507] Three ?SNAP and 10 ATP molecules are used in SNARE complex disassembly by N-ethylmaleimide-sensitive factor (NSF) [LiteratureReference:5688193] Membrane fusion: grappling with SNARE and SM proteins
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	NSF ATPase activity dissociates cis-SNARE at cis-Golgi
orthologousEvent	[BlackBoxEvent:R-BTA-6809015] NSF ATPase activity dissociates cis-SNARE at cis-Golgi - Bos taurus [BlackBoxEvent:R-SCE-6809015] NSF ATPase activity dissociates cis-SNARE at cis-Golgi - Saccharomyces cerevisiae [BlackBoxEvent:R-SPO-6809015] NSF ATPase activity dissociates cis-SNARE at cis-Golgi - Schizosaccharomyces pombe [BlackBoxEvent:R-DDI-6809015] NSF ATPase activity dissociates cis-SNARE at cis-Golgi - Dictyostelium discoideum [BlackBoxEvent:R-XTR-6809015] NSF ATPase activity dissociates cis-SNARE at cis-Golgi - Xenopus tropicalis [BlackBoxEvent:R-DRE-6809015] NSF ATPase activity dissociates cis-SNARE at cis-Golgi - Danio rerio [BlackBoxEvent:R-SSC-6809015] NSF ATPase activity dissociates cis-SNARE at cis-Golgi - Sus scrofa [BlackBoxEvent:R-CFA-6809015] NSF ATPase activity dissociates cis-SNARE at cis-Golgi - Canis familiaris [BlackBoxEvent:R-RNO-6809015] NSF ATPase activity dissociates cis-SNARE at cis-Golgi - Rattus norvegicus [BlackBoxEvent:R-MMU-6809015] NSF ATPase activity dissociates cis-SNARE at cis-Golgi - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-6807743] BET1 [Golgi membrane] [EntityWithAccessionedSequence:R-HSA-6807744] BET1L [Golgi membrane] [EntityWithAccessionedSequence:R-HSA-6807753] GOSR1 [Golgi membrane] [EntityWithAccessionedSequence:R-HSA-6807755] GOSR2 [Golgi membrane] [EntityWithAccessionedSequence:R-HSA-6808792] PalmC-YKT6 [Golgi membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol] [EntityWithAccessionedSequence:R-HSA-6807771] STX5 [Golgi membrane]
precedingEvent	[Reaction:R-HSA-6809014] cis-Golgi cis-SNARE binds NSF and SNAPs - Homo sapiens
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793638] Gillespie, Marc E, 2015-09-02
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6809015
summation	[Summation:5694378] NSF-dependent hydrolysis of ATP is required to disassociate ...

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(hasEvent)

[Pathway:R-HSA-6807878] COPI-mediated anterograde transport

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