Reactome | RAB1:GTP recruits GBF1 to the ERGIC

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RAB1:GTP recruits GBF1 to the ERGIC Show undefined attributes

authored	[InstanceEdit:6793574] Rothfels, Karen, 2015-09-01
category	binding
compartment	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created	[InstanceEdit:6807865] Rothfels, Karen, 2015-11-03
dbId	6807864
displayName	RAB1:GTP recruits GBF1 to the ERGIC
edited	[InstanceEdit:6793574] Rothfels, Karen, 2015-09-01
eventOf	[Pathway:R-HSA-6807878] COPI-mediated anterograde transport - Homo sapiens
followingEvent	[Reaction:R-HSA-6807866] GBF1 recruits ARF:GDP to the ERGIC - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6807751] GBF1 [cytosol] [Complex:R-HSA-6807799] RAB1:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] [Complex:R-HSA-5694302] USO1 homodimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6804924] Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association [LiteratureReference:6805368] GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat [LiteratureReference:5623301] Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking [LiteratureReference:6805364] GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic [LiteratureReference:6805348] Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1 [LiteratureReference:5688472] COPII and COPI traffic at the ER-Golgi interface [LiteratureReference:6804916] Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic [LiteratureReference:6804905] Characterization of class I and II ADP-ribosylation factors (Arfs) in live cells: GDP-bound class II Arfs associate with the ER-Golgi intermediate compartment independently of GBF1 [LiteratureReference:6804887] ARF proteins: roles in membrane traffic and beyond [LiteratureReference:6808936] The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	RAB1:GTP recruits GBF1 to the ERGIC
orthologousEvent	[Reaction:R-SCE-6807864] RAB1:GTP recruits GBF1 to the ERGIC - Saccharomyces cerevisiae [Reaction:R-SPO-6807864] RAB1:GTP recruits GBF1 to the ERGIC - Schizosaccharomyces pombe [Reaction:R-DDI-6807864] RAB1:GTP recruits GBF1 to the ERGIC - Dictyostelium discoideum [Reaction:R-CEL-6807864] RAB1:GTP recruits GBF1 to the ERGIC - Caenorhabditis elegans [Reaction:R-DME-6807864] RAB1:GTP recruits GBF1 to the ERGIC - Drosophila melanogaster [Reaction:R-DRE-6807864] RAB1:GTP recruits GBF1 to the ERGIC - Danio rerio [Reaction:R-BTA-6807864] RAB1:GTP recruits GBF1 to the ERGIC - Bos taurus [Reaction:R-CFA-6807864] RAB1:GTP recruits GBF1 to the ERGIC - Canis familiaris [Reaction:R-RNO-6807864] RAB1:GTP recruits GBF1 to the ERGIC - Rattus norvegicus [Reaction:R-MMU-6807864] RAB1:GTP recruits GBF1 to the ERGIC - Mus musculus
output	[Complex:R-HSA-6807800] RAB1:GTP:GBF1:USO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793638] Gillespie, Marc E, 2015-09-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6807864
summation	[Summation:6807726] In its GTP-bound active state, RAB1 recruits the ARF GEF GBF...

Referrals

(hasEvent)	[Pathway:R-HSA-6807878] COPI-mediated anterograde transport
(precedingEvent)	[Reaction:R-HSA-6807866] GBF1 recruits ARF:GDP to the ERGIC

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