Reactome | ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex

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ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex Show undefined attributes

authored	[InstanceEdit:6793574] Rothfels, Karen, 2015-09-01
category	binding
compartment	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created	[InstanceEdit:6807874] Rothfels, Karen, 2015-11-03
dbId	6807875
displayName	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex
edited	[InstanceEdit:6793574] Rothfels, Karen, 2015-09-01
eventOf	[Pathway:R-HSA-6807878] COPI-mediated anterograde transport - Homo sapiens
followingEvent	[Reaction:R-HSA-6807877] ARFGAPs stimulate ARF GTPase activity - Homo sapiens
input	[DefinedSet:R-HSA-427190] Ankyrin [cytosol] [DefinedSet:R-HSA-6807832] ARFGAP1,2,3 [cytosol] [CandidateSet:R-HSA-6807816] ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] [DefinedSet:R-HSA-6807812] p24 dimers [endoplasmic reticulum-Golgi intermediate compartment membrane] [EntityWithAccessionedSequence:R-HSA-5688558] PalmC-YKT6 [endoplasmic reticulum-Golgi intermediate compartment membrane] [Complex:R-HSA-6807822] RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] [Complex:R-HSA-420053] Spectrin tetramer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6807653] Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum [LiteratureReference:6807641] A v-SNARE implicated in intra-Golgi transport [LiteratureReference:6807663] Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors [LiteratureReference:6807652] Coatomer interaction with di-lysine endoplasmic reticulum retention motifs [LiteratureReference:6804917] Live imaging of bidirectional traffic from the ERGIC [LiteratureReference:6807674] KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET [LiteratureReference:6807643] Bidirectional transport by distinct populations of COPI-coated vesicles [LiteratureReference:6804910] ER-to-Golgi transport visualized in living cells [LiteratureReference:6807709] The COPI system: molecular mechanisms and function [LiteratureReference:6807668] Diverse roles for the p24 family of proteins in eukaryotic cells [LiteratureReference:6807698] Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23 [LiteratureReference:6805327] Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins [LiteratureReference:6805294] A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer [LiteratureReference:6807638] A conformational change in the alpha-subunit of coatomer induced by ligand binding to gamma-COP revealed by single-pair FRET [LiteratureReference:6807695] Receptor-induced polymerization of coatomer [LiteratureReference:6807682] Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane [LiteratureReference:5689381] Selective export of human GPI-anchored proteins from the endoplasmic reticulum [LiteratureReference:6807689] Proteinase-activated receptors, nucleotide P2Y receptors, and ?-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking [LiteratureReference:3247709] p24 proteins are required for secretion of Wnt ligands [LiteratureReference:6807649] Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain [LiteratureReference:6807666] Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex [LiteratureReference:6804887] ARF proteins: roles in membrane traffic and beyond [LiteratureReference:6807707] Sorting of Golgi resident proteins into different subpopulations of COPI vesicles: a role for ArfGAP1 [LiteratureReference:6808358] Arf GAP2 is positively regulated by coatomer and cargo [LiteratureReference:6808324] Two human ARFGAPs associated with COP-I-coated vesicles [LiteratureReference:5246472] Functional characterization of novel human ARFGAP3 [LiteratureReference:6808352] Consensus nomenclature for the human ArfGAP domain-containing proteins [LiteratureReference:200545] Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature [LiteratureReference:6808316] Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature [LiteratureReference:6808356] Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking [LiteratureReference:6808345] Discrete determinants in ArfGAP2/3 conferring Golgi localization and regulation by the COPI coat [LiteratureReference:6808330] The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1 [LiteratureReference:6808934] Na,K-ATPase transport from endoplasmic reticulum to Golgi requires the Golgi spectrin-ankyrin G119 skeleton in Madin Darby canine kidney cells [LiteratureReference:6808915] ADP ribosylation factor regulates spectrin binding to the Golgi complex [LiteratureReference:6808927] Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles [LiteratureReference:6808940] beta III spectrin binds to the Arp1 subunit of dynactin
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex
orthologousEvent	[Reaction:R-DDI-6807875] ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex - Dictyostelium discoideum [Reaction:R-DME-6807875] ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex - Drosophila melanogaster [Reaction:R-SSC-6807875] ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex - Sus scrofa [Reaction:R-CFA-6807875] ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex - Canis familiaris [Reaction:R-MMU-6807875] ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex - Mus musculus [Reaction:R-RNO-6807875] ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex - Rattus norvegicus
output	[Complex:R-HSA-6807825] RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane]
precedingEvent	[Reaction:R-HSA-6807872] Active ARF recruits coatomer - Homo sapiens
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793638] Gillespie, Marc E, 2015-09-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6807875
summation	[Summation:6807720] Binding and polymerization of the coatomer (the COPI coat) i...

Referrals

(precedingEvent)	[Reaction:R-HSA-6807877] ARFGAPs stimulate ARF GTPase activity
(hasEvent)	[Pathway:R-HSA-6807878] COPI-mediated anterograde transport

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