Reactome | GBF1 stimulates ARF nucleotide exchange

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GBF1 stimulates ARF nucleotide exchange Show undefined attributes

authored	[InstanceEdit:6793574] Rothfels, Karen, 2015-09-01
catalystActivity	[CatalystActivity:6807858] guanyl-nucleotide exchange factor activity of RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane]
category	transition
compartment	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created	[InstanceEdit:6807869] Rothfels, Karen, 2015-11-03
dbId	6807868
displayName	GBF1 stimulates ARF nucleotide exchange
edited	[InstanceEdit:6793574] Rothfels, Karen, 2015-09-01
eventOf	[Pathway:R-HSA-6807878] COPI-mediated anterograde transport - Homo sapiens
followingEvent	[Reaction:R-HSA-6807872] Active ARF recruits coatomer - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-6807803] RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6805352] Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi [LiteratureReference:6805348] Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1 [LiteratureReference:5623301] Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking [LiteratureReference:6805368] GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat [LiteratureReference:5688472] COPII and COPI traffic at the ER-Golgi interface
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	GBF1 stimulates ARF nucleotide exchange
orthologousEvent	[Reaction:R-PFA-6807868] GBF1 stimulates ARF nucleotide exchange - Plasmodium falciparum [Reaction:R-SCE-6807868] GBF1 stimulates ARF nucleotide exchange - Saccharomyces cerevisiae [Reaction:R-SPO-6807868] GBF1 stimulates ARF nucleotide exchange - Schizosaccharomyces pombe [Reaction:R-DDI-6807868] GBF1 stimulates ARF nucleotide exchange - Dictyostelium discoideum [Reaction:R-CEL-6807868] GBF1 stimulates ARF nucleotide exchange - Caenorhabditis elegans [Reaction:R-DME-6807868] GBF1 stimulates ARF nucleotide exchange - Drosophila melanogaster [Reaction:R-GGA-6807868] GBF1 stimulates ARF nucleotide exchange - Gallus gallus [Reaction:R-DRE-6807868] GBF1 stimulates ARF nucleotide exchange - Danio rerio [Reaction:R-SSC-6807868] GBF1 stimulates ARF nucleotide exchange - Sus scrofa [Reaction:R-BTA-6807868] GBF1 stimulates ARF nucleotide exchange - Bos taurus [Reaction:R-CFA-6807868] GBF1 stimulates ARF nucleotide exchange - Canis familiaris [Reaction:R-RNO-6807868] GBF1 stimulates ARF nucleotide exchange - Rattus norvegicus [Reaction:R-MMU-6807868] GBF1 stimulates ARF nucleotide exchange - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-6807820] RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane]
precedingEvent	[Reaction:R-HSA-6807866] GBF1 recruits ARF:GDP to the ERGIC - Homo sapiens
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6793638] Gillespie, Marc E, 2015-09-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6807868
summation	[Summation:6807725] GBF1 facilitates the exchange of GDP for GTP, activating ARF...

Referrals

(hasEvent)	[Pathway:R-HSA-6807878] COPI-mediated anterograde transport
(precedingEvent)	[Reaction:R-HSA-6807872] Active ARF recruits coatomer

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