Reactome | p-S166,S188-MDM2 dimer [nucleoplasm]

Schema > Complex > Entries

p-S166,S188-MDM2 dimer [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:10706726] ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-XTR-8952373] RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-8952371] MDM2 binds RUNX3 - Xenopus tropicalis [Reaction:R-XTR-6804942] MDM2 homodimers auto-ubiquitinate - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10692633
displayName	p-S166,S188-MDM2 dimer [nucleoplasm]
hasComponent	2 × [DefinedSet:R-XTR-6793669-3] Homologues of p-S166,S188-MDM2 [nucleoplasm]
inDisease	false
inferredFrom	[CandidateSet:R-HSA-6805030] p-S166,S188-MDM2:(p-S166,S188-MDM2,p-S346,S367,S403-MDM4) [nucleoplasm] - Homo sapiens [DefinedSet:R-HSA-6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] - Homo sapiens [Complex:R-HSA-6804933] p-S166,S188-MDM2 dimer [nucleoplasm] - Homo sapiens
maxDepth	3
name	p-S166,S188-MDM2 dimer
producedByEvent	[Reaction:R-XTR-6804741] MDM2 forms homo- or heterodimers - Xenopus tropicalis [Reaction:R-XTR-8952382] MDM2 polyubiquitinates RUNX3 - Xenopus tropicalis [Reaction:R-XTR-3215295] USP7 deubiquitinates MDM2 - Xenopus tropicalis
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-6804933
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[Reaction:R-XTR-8952382] MDM2 polyubiquitinates RUNX3 [Reaction:R-XTR-3215295] USP7 deubiquitinates MDM2 [Reaction:R-XTR-6804741] MDM2 forms homo- or heterodimers
(activeUnit)	[CatalystActivity:10717876] ubiquitin protein ligase activity of RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm]
(input)	[Reaction:R-XTR-8952371] MDM2 binds RUNX3 [Reaction:R-XTR-6804942] MDM2 homodimers auto-ubiquitinate
(hasComponent)	[Complex:R-XTR-8952373] RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm]
(inferredTo)	[CandidateSet:R-HSA-6805030] p-S166,S188-MDM2:(p-S166,S188-MDM2,p-S346,S367,S403-MDM4) [nucleoplasm] [DefinedSet:R-HSA-6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] [Complex:R-HSA-6804933] p-S166,S188-MDM2 dimer [nucleoplasm]
(physicalEntity)	[CatalystActivity:10706726] ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]

© 2026 Reactome

Cite Us!