Reactome | p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]

Schema > DefinedSet > Entries

catalystActivities	[CatalystActivity:10190609] ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-RNO-6804885] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-5633460] MDM2 binds TP53 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10180053
displayName	p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
hasMember	[Complex:R-RNO-6804933] p-S166,S188-MDM2 dimer [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-6804932] p-S166,S188-MDM2:MDM4 [nucleoplasm] - Rattus norvegicus
inDisease	false
inferredFrom	[DefinedSet:R-HSA-6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] - Homo sapiens
maxDepth	3
name	p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4
producedByEvent	[Reaction:R-RNO-6804741] MDM2 forms homo- or heterodimers - Rattus norvegicus [Reaction:R-RNO-6804879] MDM2 ubiquitinates TP53 - Rattus norvegicus
schemaClass	DefinedSet
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6804745

(physicalEntity)	[CatalystActivity:10190609] ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
(output)	[Reaction:R-RNO-6804879] MDM2 ubiquitinates TP53 [Reaction:R-RNO-6804741] MDM2 forms homo- or heterodimers
(input)	[Reaction:R-RNO-5633460] MDM2 binds TP53
(hasComponent)	[Complex:R-RNO-6804885] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm]
(inferredTo)	[DefinedSet:R-HSA-6804745] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]

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