Reactome | TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

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TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
created	[InstanceEdit:6804113] Orlic-Milacic, Marija, 2015-10-08
crossReference	[DatabaseIdentifier:12819489] BioModels Database:BIOMD0000000939
dbId	6804115
displayName	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-6798020] TP53 binds the BTG2 gene - Homo sapiens [BlackBoxEvent:R-HSA-6798031] TP53 stimulates BTG2 expression - Homo sapiens [Reaction:R-HSA-6798044] BTG2 binds CCR4-NOT complex - Homo sapiens [Reaction:R-HSA-6801641] TP53 binds the PLK2 gene - Homo sapiens [BlackBoxEvent:R-HSA-6801637] TP53 stimulates PLK2 expression - Homo sapiens [Reaction:R-HSA-6801666] PLK2 phosphorylates CENPJ - Homo sapiens [Reaction:R-HSA-6801675] PLK2 phosphorylates NPM1 - Homo sapiens [Reaction:R-HSA-6802165] TP53 binds the PLK3 gene - Homo sapiens [BlackBoxEvent:R-HSA-6802170] TP53 stimulates PLK3 expression - Homo sapiens [Reaction:R-HSA-6802973] PLK3 phosphorylates CDC25C - Homo sapiens [Reaction:R-HSA-6803914] TP53 binds the RGCC gene - Homo sapiens [BlackBoxEvent:R-HSA-6803917] TP53 stimulates RGCC expression - Homo sapiens [Reaction:R-HSA-6803935] TP53 binds the PLAGL1 gene - Homo sapiens [BlackBoxEvent:R-HSA-6803946] TP53 stimulates PLAGL1 expression - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6798034] Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway [LiteratureReference:6798062] Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex [LiteratureReference:6798041] The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene [LiteratureReference:6798059] The BTG2 protein is a general activator of mRNA deadenylation [LiteratureReference:6798058] Structural basis for the antiproliferative activity of the Tob-hCaf1 complex [LiteratureReference:6798055] The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex [LiteratureReference:6798071] Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities [LiteratureReference:6801634] Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells [LiteratureReference:6801667] PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle [LiteratureReference:6801678] Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication [LiteratureReference:6801657] Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies [LiteratureReference:5628898] Identification of novel p53 target genes in ionizing radiation response [LiteratureReference:6802971] Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation [LiteratureReference:6803912] RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest [LiteratureReference:6803932] A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1 [LiteratureReference:6803952] hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer [LiteratureReference:6803962] Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
orthologousEvent	[Pathway:R-DRE-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Danio rerio [Pathway:R-MMU-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Mus musculus [Pathway:R-RNO-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Rattus norvegicus [Pathway:R-CFA-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Canis familiaris [Pathway:R-BTA-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Bos taurus [Pathway:R-SSC-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Sus scrofa [Pathway:R-XTR-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Xenopus tropicalis [Pathway:R-GGA-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Gallus gallus [Pathway:R-DDI-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Dictyostelium discoideum [Pathway:R-SPO-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Schizosaccharomyces pombe [Pathway:R-SCE-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Saccharomyces cerevisiae
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6804115
summation	[Summation:6804178] BTG2 is induced by TP53, leading to cessation of cellular pr...

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[Pathway:R-HSA-6791312] TP53 Regulates Transcription of Cell Cycle Genes

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