Reactome | PLK2 phosphorylates NPM1

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PLK2 phosphorylates NPM1 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:6801664] protein serine/threonine kinase activity of PLK2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6801680] Orlic-Milacic, Marija, 2015-10-02
dbId	6801675
displayName	PLK2 phosphorylates NPM1
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-3008211] NPM1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6801678] Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PLK2 phosphorylates NPM1
orthologousEvent	[Reaction:R-DRE-6801675] PLK2 phosphorylates NPM1 - Danio rerio [Reaction:R-GGA-6801675] PLK2 phosphorylates NPM1 - Gallus gallus [Reaction:R-XTR-6801675] PLK2 phosphorylates NPM1 - Xenopus tropicalis [Reaction:R-SSC-6801675] PLK2 phosphorylates NPM1 - Sus scrofa [Reaction:R-BTA-6801675] PLK2 phosphorylates NPM1 - Bos taurus [Reaction:R-CFA-6801675] PLK2 phosphorylates NPM1 - Canis familiaris [Reaction:R-RNO-6801675] PLK2 phosphorylates NPM1 - Rattus norvegicus [Reaction:R-MMU-6801675] PLK2 phosphorylates NPM1 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-6801679] p-S4-NPM1 [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-6801637] TP53 stimulates PLK2 expression - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6801675
summation	[Summation:6802160] PLK2 phosphorylates NPM1 (nucleophosmin) on serine residue S...

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(hasEvent)

[Pathway:R-HSA-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain