Reactome | TP53 Regulates Transcription of Cell Cycle Genes

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authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
created	[InstanceEdit:6791313] Orlic-Milacic, Marija, 2015-08-20
dbId	6791312
displayName	TP53 Regulates Transcription of Cell Cycle Genes
doi	10.3180/r-hsa-6791312.1
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:22659] DNA damage response, signal transduction by p53 class mediator
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest - Homo sapiens [Pathway:R-HSA-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Homo sapiens [Pathway:R-HSA-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-06-12
literatureReference	[LiteratureReference:69405] WAF1, a potential mediator of p53 tumor suppression. [LiteratureReference:69417] The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. [LiteratureReference:6803393] MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M [LiteratureReference:6803408] The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability [LiteratureReference:6798350] The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence [LiteratureReference:6798297] E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression [LiteratureReference:6791392] E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53 [LiteratureReference:6791380] Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage [LiteratureReference:6791382] A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer [LiteratureReference:6791366] A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence [LiteratureReference:6791238] Gadd45a interacts with aurora-A and inhibits its kinase activity [LiteratureReference:3215145] Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53 [LiteratureReference:6791112] Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase [LiteratureReference:6791116] A novel role for Gadd45? in base excision repair: modulation of APE1 activity by the direct interaction of Gadd45? with PCNA [LiteratureReference:6791110] Characterisation of the interaction between PCNA and Gadd45 [LiteratureReference:6791118] Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen [LiteratureReference:6803862] 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression [LiteratureReference:6803870] 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage [LiteratureReference:6803888] The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax [LiteratureReference:6798286] DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter [LiteratureReference:6798264] p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes [LiteratureReference:6798034] Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway [LiteratureReference:6798062] Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex [LiteratureReference:6798041] The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene [LiteratureReference:6798059] The BTG2 protein is a general activator of mRNA deadenylation [LiteratureReference:6798058] Structural basis for the antiproliferative activity of the Tob-hCaf1 complex [LiteratureReference:6798055] The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex [LiteratureReference:6798071] Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities [LiteratureReference:6801634] Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells [LiteratureReference:6801667] PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle [LiteratureReference:6801678] Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication [LiteratureReference:6801657] Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies [LiteratureReference:5628898] Identification of novel p53 target genes in ionizing radiation response [LiteratureReference:6802971] Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation [LiteratureReference:6803912] RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest [LiteratureReference:6803932] A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1 [LiteratureReference:6803952] hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer [LiteratureReference:6803962] Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain [LiteratureReference:6803710] Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation [LiteratureReference:6801440] Transcriptional control of human p53-regulated genes [LiteratureReference:6801441] A complex barcode underlies the heterogeneous response of p53 to stress [LiteratureReference:6801433] Unravelling mechanisms of p53-mediated tumour suppression [LiteratureReference:6801439] p53 in survival, death and metabolic health: a lifeguard with a licence to kill
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	TP53 Regulates Transcription of Cell Cycle Genes
orthologousEvent	[Pathway:R-DRE-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Danio rerio [Pathway:R-PFA-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Plasmodium falciparum [Pathway:R-DDI-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Dictyostelium discoideum [Pathway:R-BTA-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Bos taurus [Pathway:R-MMU-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Mus musculus [Pathway:R-GGA-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Gallus gallus [Pathway:R-RNO-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Rattus norvegicus [Pathway:R-SCE-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Saccharomyces cerevisiae [Pathway:R-SPO-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Schizosaccharomyces pombe [Pathway:R-XTR-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Xenopus tropicalis [Pathway:R-CEL-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Caenorhabditis elegans [Pathway:R-SSC-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Sus scrofa [Pathway:R-CFA-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Canis familiaris [Pathway:R-DME-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Drosophila melanogaster
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6791312
summation	[Summation:6804148] Under a variety of stress conditions, TP53 (p53), stabilized...
updateTrackers	[UpdateTracker:9777713] Update Tracker - [Pathway:6791312] TP53 Regulates Transcription of Cell Cycle Genes - v69:[updateIndirectRLE] [UpdateTracker:9780137] Update Tracker - [Pathway:6791312] TP53 Regulates Transcription of Cell Cycle Genes - v64:[updateIndirectRLE] [UpdateTracker:9782033] Update Tracker - [Pathway:6791312] TP53 Regulates Transcription of Cell Cycle Genes - v60:[updateContainedPathway, updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53
(hasEncapsulatedEvent)	[Pathway:R-HSA-6804759] Regulation of TP53 Activity through Association with Co-factors [Pathway:R-HSA-8853884] Transcriptional Regulation by VENTX
(updatedInstance)	[UpdateTracker:9777713] Update Tracker - [Pathway:6791312] TP53 Regulates Transcription of Cell Cycle Genes - v69:[updateIndirectRLE] [UpdateTracker:9780137] Update Tracker - [Pathway:6791312] TP53 Regulates Transcription of Cell Cycle Genes - v64:[updateIndirectRLE] [UpdateTracker:9782033] Update Tracker - [Pathway:6791312] TP53 Regulates Transcription of Cell Cycle Genes - v60:[updateContainedPathway, updateIndirectRLE]

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