Reactome | TP53 stimulates PLAGL1 expression

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TP53 stimulates PLAGL1 expression Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6803949] Orlic-Milacic, Marija, 2015-10-07
dbId	6803946
displayName	TP53 stimulates PLAGL1 expression
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6803933] PLAGL1 Gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6803932] A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1 [LiteratureReference:6803962] Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain [LiteratureReference:6803952] hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates PLAGL1 expression
output	[EntityWithAccessionedSequence:R-HSA-6803945] PLAGL1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6803935] TP53 binds the PLAGL1 gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-6803948] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:PLAGL1 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9641918] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:PLAGL1 Gene [nucleoplasm]' A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6803946
summation	[Summation:6803947] Binding of TP53 (p53) to the p53 response element in the pro...

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[Pathway:R-HSA-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain