Reactome | PLK3 phosphorylates CDC25C

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PLK3 phosphorylates CDC25C Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:3222175] protein serine/threonine kinase activity of PLK3 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6802972] Orlic-Milacic, Marija, 2015-10-02
dbId	6802973
displayName	PLK3 phosphorylates CDC25C
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-69741] CDC25C [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6802971] Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PLK3 phosphorylates CDC25C
orthologousEvent	[Reaction:R-DRE-6802973] PLK3 phosphorylates CDC25C - Danio rerio [Reaction:R-SCE-6802973] PLK3 phosphorylates CDC25C - Saccharomyces cerevisiae [Reaction:R-SPO-6802973] PLK3 phosphorylates CDC25C - Schizosaccharomyces pombe [Reaction:R-DDI-6802973] PLK3 phosphorylates CDC25C - Dictyostelium discoideum [Reaction:R-SSC-6802973] PLK3 phosphorylates CDC25C - Sus scrofa [Reaction:R-BTA-6802973] PLK3 phosphorylates CDC25C - Bos taurus [Reaction:R-CFA-6802973] PLK3 phosphorylates CDC25C - Canis familiaris [Reaction:R-RNO-6802973] PLK3 phosphorylates CDC25C - Rattus norvegicus [Reaction:R-MMU-6802973] PLK3 phosphorylates CDC25C - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6802968] p-S191-CDC25C [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-6802170] TP53 stimulates PLK3 expression - Homo sapiens [BlackBoxEvent:R-HSA-6798268] TP53 and E2F4 inhibit CDC25C expression - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6802973
summation	[Summation:6802976] PLK3 phosphorylates CDC25C at serine residue S191 within the...

Referrals

(hasEvent)

[Pathway:R-HSA-6804115] TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain