CDK1 or CDK2 in complex with CCNA (cyclin A) phosphorylates ...

created [InstanceEdit:6793660] Orlic-Milacic, Marija, 2015-09-03
dbId 6793659
displayName CDK1 or CDK2 in complex with CCNA (cyclin A) phosphorylates ...
modified [InstanceEdit:6793670] Orlic-Milacic, Marija, 2015-09-03
schemaClass Summation
text CDK1 or CDK2 in complex with CCNA (cyclin A) phosphorylates MDM2 at threonine residue T218. Phosphorylation of MDM2 at T218 increases its affinity for p14-ARF and reduces its affinity for TP53 (p53), thus resulting in TP53 upregulation (Zhang and Prives 2001).
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