Reactome | Fanconi Anemia Pathway

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Fanconi Anemia Pathway Show undefined attributes

authored	[InstanceEdit:419516] Matthews, L, 2009-05-02 17:26:55 [InstanceEdit:6783311] Orlic-Milacic, Marija, 2015-06-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6783311] Orlic-Milacic, Marija, 2015-06-11
dbId	6783310
deleted	[Deleted:6793410] Deletion of instance: 419524
displayName	Fanconi Anemia Pathway
doi	10.3180/react_18410.1
edited	[InstanceEdit:6783311] Orlic-Milacic, Marija, 2015-06-11 [InstanceEdit:421857] Matthews, L, 2009-05-20 15:51:04
eventOf	[TopLevelPathway:R-HSA-73894] DNA Repair - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2454420] interstrand cross-link repair
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-6785607] FANCM binds FAAP24 - Homo sapiens [Reaction:R-HSA-6785087] FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA - Homo sapiens [Reaction:R-HSA-6785126] FA core complex assembles at DNA interstrand crosslinks (ICLs) - Homo sapiens [Reaction:R-HSA-6785594] FANCD2 binds FANCI - Homo sapiens [Reaction:R-HSA-6785342] FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex - Homo sapiens [Reaction:R-HSA-6788385] The complex of ATR and ATRIP is recruited to ICL-DNA - Homo sapiens [Reaction:R-HSA-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA - Homo sapiens [Reaction:R-HSA-6785361] Monoubiquitination of FANCD2:FANCI - Homo sapiens [Reaction:R-HSA-6786171] FANCD2 deubiquitination by USP1:WDR48 - Homo sapiens [Reaction:R-HSA-6785732] DNA nucleases bind monoubiquitinated ID2 complex - Homo sapiens [BlackBoxEvent:R-HSA-6785986] DNA nucleases unhook the interstrand crosslink (ICL) - Homo sapiens [Reaction:R-HSA-6786155] POLN binds ICL-DNA - Homo sapiens [BlackBoxEvent:R-HSA-6786166] Translesion synthesis across unhooked ICL by POLN - Homo sapiens [Pathway:R-HSA-9750126] Drug-induced formation of DNA interstrand crosslinks - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:421848] Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways [LiteratureReference:421859] A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway [LiteratureReference:425930] Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins [LiteratureReference:6786164] Fanconi anaemia and the repair of Watson and Crick DNA crosslinks [LiteratureReference:6786163] DNA interstrand crosslink repair and cancer [LiteratureReference:6788725] Deciphering the BRCA1 Tumor Suppressor Network [LiteratureReference:6788722] PALB2 mutations and breast-cancer risk [LiteratureReference:6792728] Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice
maxDepth	3
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Fanconi Anemia Pathway
orthologousEvent	[Pathway:R-RNO-6783310] Fanconi Anemia Pathway - Rattus norvegicus [Pathway:R-CFA-6783310] Fanconi Anemia Pathway - Canis familiaris [Pathway:R-BTA-6783310] Fanconi Anemia Pathway - Bos taurus [Pathway:R-SSC-6783310] Fanconi Anemia Pathway - Sus scrofa [Pathway:R-DRE-6783310] Fanconi Anemia Pathway - Danio rerio [Pathway:R-XTR-6783310] Fanconi Anemia Pathway - Xenopus tropicalis [Pathway:R-GGA-6783310] Fanconi Anemia Pathway - Gallus gallus [Pathway:R-DME-6783310] Fanconi Anemia Pathway - Drosophila melanogaster [Pathway:R-CEL-6783310] Fanconi Anemia Pathway - Caenorhabditis elegans [Pathway:R-DDI-6783310] Fanconi Anemia Pathway - Dictyostelium discoideum [Pathway:R-MMU-6783310] Fanconi Anemia Pathway - Mus musculus
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:421862] Huang, TT, 2009-05-20 17:48:24 [InstanceEdit:6792505] Fugger, Kasper, 2015-08-20
revised	[InstanceEdit:6783311] Orlic-Milacic, Marija, 2015-06-11
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6783310
summation	[Summation:6788507] Fanconi anemia (FA) is a genetic disease of genome instabili...
updateTrackers	[UpdateTracker:9780319] Update Tracker - [Pathway:6783310] Fanconi Anemia Pathway - v63:[modifyText, updateContainedRLE] [UpdateTracker:9781350] Update Tracker - [Pathway:6783310] Fanconi Anemia Pathway - v61:[updateContainedRLE] [UpdateTracker:9775799] Update Tracker - [Pathway:6783310] Fanconi Anemia Pathway - v78:[addHasEvent]

Referrals

(hasEvent)	[TopLevelPathway:R-HSA-73894] DNA Repair
(hasEncapsulatedEvent)	[Pathway:R-HSA-6796648] TP53 Regulates Transcription of DNA Repair Genes
(replacementInstances)	[Deleted:6793410] Deletion of instance: 419524
(updatedInstance)	[UpdateTracker:9780319] Update Tracker - [Pathway:6783310] Fanconi Anemia Pathway - v63:[modifyText, updateContainedRLE] [UpdateTracker:9781350] Update Tracker - [Pathway:6783310] Fanconi Anemia Pathway - v61:[updateContainedRLE] [UpdateTracker:9775799] Update Tracker - [Pathway:6783310] Fanconi Anemia Pathway - v78:[addHasEvent]

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