Reactome | Translesion synthesis across unhooked ICL by POLN

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Translesion synthesis across unhooked ICL by POLN Show undefined attributes

authored	[InstanceEdit:6785606] Orlic-Milacic, Marija, 2015-06-29
catalystActivity	[CatalystActivity:6786167] DNA-directed DNA polymerase activity of MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6786159] Orlic-Milacic, Marija, 2015-07-03
dbId	6786166
displayName	Translesion synthesis across unhooked ICL by POLN
edited	[InstanceEdit:6785606] Orlic-Milacic, Marija, 2015-06-29
eventOf	[Pathway:R-HSA-6783310] Fanconi Anemia Pathway - Homo sapiens
input	[SimpleEntity:R-ALL-30555] dNTP [nucleoplasm] [Complex:R-HSA-6786156] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5686109] DNA polymerase POLN participates in cross-link repair and homologous recombination [LiteratureReference:6786161] Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links [LiteratureReference:6786164] Fanconi anaemia and the repair of Watson and Crick DNA crosslinks [LiteratureReference:6786163] DNA interstrand crosslink repair and cancer
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Translesion synthesis across unhooked ICL by POLN
orthologousEvent	[BlackBoxEvent:R-MMU-6786166] Translesion synthesis across unhooked ICL by POLN - Mus musculus [BlackBoxEvent:R-GGA-6786166] Translesion synthesis across unhooked ICL by POLN - Gallus gallus [BlackBoxEvent:R-SSC-6786166] Translesion synthesis across unhooked ICL by POLN - Sus scrofa [BlackBoxEvent:R-BTA-6786166] Translesion synthesis across unhooked ICL by POLN - Bos taurus [BlackBoxEvent:R-CFA-6786166] Translesion synthesis across unhooked ICL by POLN - Canis familiaris [BlackBoxEvent:R-RNO-6786166] Translesion synthesis across unhooked ICL by POLN - Rattus norvegicus
output	[OtherEntity:R-ALL-5688114] Distorted dsDNA [nucleoplasm] [OtherEntity:R-ALL-75165] DNA double-strand break ends [nucleoplasm] [Complex:R-HSA-420757] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI [nucleoplasm] [Complex:R-HSA-6788399] p-FA Core Complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6786153] POLN [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6786155] POLN binds ICL-DNA - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6792505] Fugger, Kasper, 2015-08-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6786166
summation	[Summation:6786169] The error-prone DNA polymerase nu (POLN) performs translesio...

Referrals

(hasEvent)

[Pathway:R-HSA-6783310] Fanconi Anemia Pathway