Reactome | Fanconi Anemia Pathway

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Fanconi Anemia Pathway Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331353
displayName	Fanconi Anemia Pathway
eventOf	[TopLevelPathway:R-CFA-73894] DNA Repair - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2454420] interstrand cross-link repair
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CFA-6785607] FANCM binds FAAP24 - Canis familiaris [Reaction:R-CFA-6785126] FA core complex assembles at DNA interstrand crosslinks (ICLs) - Canis familiaris [Reaction:R-CFA-6785594] FANCD2 binds FANCI - Canis familiaris [Reaction:R-CFA-6788385] The complex of ATR and ATRIP is recruited to ICL-DNA - Canis familiaris [Reaction:R-CFA-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA - Canis familiaris [Reaction:R-CFA-6786171] FANCD2 deubiquitination by USP1:WDR48 - Canis familiaris [Reaction:R-CFA-6785732] DNA nucleases bind monoubiquitinated ID2 complex - Canis familiaris [BlackBoxEvent:R-CFA-6785986] DNA nucleases unhook the interstrand crosslink (ICL) - Canis familiaris [Reaction:R-CFA-6786155] POLN binds ICL-DNA - Canis familiaris [BlackBoxEvent:R-CFA-6786166] Translesion synthesis across unhooked ICL by POLN - Canis familiaris
inferredFrom	[Pathway:R-HSA-6783310] Fanconi Anemia Pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Fanconi Anemia Pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-6783310
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-CFA-73894] DNA Repair
(hasEncapsulatedEvent)	[Pathway:R-CFA-6796648] TP53 Regulates Transcription of DNA Repair Genes
(inferredTo)	[Pathway:R-HSA-6783310] Fanconi Anemia Pathway