Reactome | DNA nucleases bind monoubiquitinated ID2 complex

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DNA nucleases bind monoubiquitinated ID2 complex Show undefined attributes

authored	[InstanceEdit:6785606] Orlic-Milacic, Marija, 2015-06-29
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6785731] Orlic-Milacic, Marija, 2015-06-30
dbId	6785732
displayName	DNA nucleases bind monoubiquitinated ID2 complex
edited	[InstanceEdit:6785606] Orlic-Milacic, Marija, 2015-06-29
eventOf	[Pathway:R-HSA-6783310] Fanconi Anemia Pathway - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-6785986] DNA nucleases unhook the interstrand crosslink (ICL) - Homo sapiens
input	[CandidateSet:R-HSA-6785737] DCLRE1A,DCLRE1B [nucleoplasm] [Complex:R-HSA-109943] ERCC1:ERCC4 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-6785736] FAN1 [nucleoplasm] [Complex:R-HSA-6785367] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] [Complex:R-HSA-5686474] SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6785953] FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair [LiteratureReference:6785977] Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2 [LiteratureReference:6785967] A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair [LiteratureReference:6785955] Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents [LiteratureReference:6785980] Structural insights into 5' flap DNA unwinding and incision by the human FAN1 dimer [LiteratureReference:6786032] Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway [LiteratureReference:5686478] Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells [LiteratureReference:5686496] Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases [LiteratureReference:6786143] Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases [LiteratureReference:6786145] RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger [LiteratureReference:353274] DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	DNA nucleases bind monoubiquitinated ID2 complex
orthologousEvent	[Reaction:R-MMU-6785732] DNA nucleases bind monoubiquitinated ID2 complex - Mus musculus [Reaction:R-DRE-6785732] DNA nucleases bind monoubiquitinated ID2 complex - Danio rerio [Reaction:R-SSC-6785732] DNA nucleases bind monoubiquitinated ID2 complex - Sus scrofa [Reaction:R-BTA-6785732] DNA nucleases bind monoubiquitinated ID2 complex - Bos taurus [Reaction:R-CFA-6785732] DNA nucleases bind monoubiquitinated ID2 complex - Canis familiaris [Reaction:R-RNO-6785732] DNA nucleases bind monoubiquitinated ID2 complex - Rattus norvegicus
output	[Complex:R-HSA-6785734] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6785361] Monoubiquitination of FANCD2:FANCI - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8985610] Negative regulation by 'USP1:WDR48 [nucleoplasm]'
regulationReference	[RegulationReference:9641530] Negative regulation by 'USP1:WDR48 [nucleoplasm]' A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6792505] Fugger, Kasper, 2015-08-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6785732
summation	[Summation:6785954] Several DNA nucleases bind to interstrand crosslinks (ICL-DN...
updateTrackers	[UpdateTracker:9780993] Update Tracker - [Reaction:6785732] DNA nucleases bind monoubiquitinated ID2 complex - v61:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9780993] Update Tracker - [Reaction:6785732] DNA nucleases bind monoubiquitinated ID2 complex - v61:[addRegulator]
(hasEvent)	[Pathway:R-HSA-6783310] Fanconi Anemia Pathway
(precedingEvent)	[BlackBoxEvent:R-HSA-6785986] DNA nucleases unhook the interstrand crosslink (ICL)

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