Reactome | TP53 Regulates Transcription of DNA Repair Genes

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TP53 Regulates Transcription of DNA Repair Genes Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
created	[InstanceEdit:6796656] Orlic-Milacic, Marija, 2015-09-04
crossReference	[DatabaseIdentifier:12819591] BioModels Database:BIOMD0000000188 [DatabaseIdentifier:12819489] BioModels Database:BIOMD0000000939 [DatabaseIdentifier:12819449] BioModels Database:BIOMD0000000940
dbId	6796648
displayName	TP53 Regulates Transcription of DNA Repair Genes
doi	10.3180/r-hsa-6796648.1
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53 - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-6806412] TP53 and AP-1 bind the MSH2 promoter - Homo sapiens [BlackBoxEvent:R-HSA-6806394] TP53 and AP-1 stimulate MSH2 expression - Homo sapiens [Reaction:R-HSA-6806408] TP53 binds the PMS2 gene - Homo sapiens [BlackBoxEvent:R-HSA-6806405] TP53 stimulates PMS2 expression - Homo sapiens [Reaction:R-HSA-6806413] TP53 binds the MLH1 gene - Homo sapiens [BlackBoxEvent:R-HSA-6806392] TP53 stimulates MLH1 expression - Homo sapiens [Reaction:R-HSA-6806419] TP53 binds the FANCC gene - Homo sapiens [BlackBoxEvent:R-HSA-6806425] TP53 stimulates FANCC expression - Homo sapiens [Reaction:R-HSA-6806417] TP53 binds the DDB2 gene - Homo sapiens [BlackBoxEvent:R-HSA-6806423] TP53 stimulates DDB2 expression - Homo sapiens [Reaction:R-HSA-6796649] TP53 binds the CCNK gene - Homo sapiens [BlackBoxEvent:R-HSA-6796647] TP53 stimulates CCNK expression - Homo sapiens [Reaction:R-HSA-6797090] CCNK binds CDK12 - Homo sapiens [Reaction:R-HSA-6797100] CCNK binds CDK13 - Homo sapiens [Reaction:R-HSA-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Homo sapiens [Reaction:R-HSA-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Homo sapiens [BlackBoxEvent:R-HSA-6797712] CDK12 stimulates expression of DNA repair genes - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-06-12
literatureReference	[LiteratureReference:6806409] p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV [LiteratureReference:6806400] Identification of a p53 response element in the promoter region of the hMSH2 gene required for expression in A2780 ovarian cancer cells [LiteratureReference:6806407] Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements [LiteratureReference:6806427] p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice [LiteratureReference:6806428] p53 activates Fanconi anemia group C gene expression [LiteratureReference:6796651] Cyclin K as a direct transcriptional target of the p53 tumor suppressor [LiteratureReference:6797658] Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex [LiteratureReference:6797093] The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes [LiteratureReference:6797694] The structure and substrate specificity of human Cdk12/Cyclin K [LiteratureReference:6797674] Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex [LiteratureReference:6797685] Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II [LiteratureReference:8856126] RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence [LiteratureReference:8856106] p53 responsive nucleotide excision repair gene products p48 and XPC, but not p53, localize to sites of UV-irradiation-induced DNA damage, in vivo [LiteratureReference:8856113] A nucleotide excision repair master-switch: p53 regulated coordinate induction of global genomic repair genes [LiteratureReference:8856105] Multiple roles of the cell cycle inhibitor p21(CDKN1A) in the DNA damage response [LiteratureReference:8856134] p53-mediated regulation of proliferating cell nuclear antigen expression in cells exposed to ionizing radiation [LiteratureReference:8856114] Functional evolution of the p53 regulatory network through its target response elements [LiteratureReference:8856130] p53 coordinates base excision repair to prevent genomic instability
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	TP53 Regulates Transcription of DNA Repair Genes
orthologousEvent	[Pathway:R-MMU-6796648] TP53 Regulates Transcription of DNA Repair Genes - Mus musculus [Pathway:R-SCE-6796648] TP53 Regulates Transcription of DNA Repair Genes - Saccharomyces cerevisiae [Pathway:R-SPO-6796648] TP53 Regulates Transcription of DNA Repair Genes - Schizosaccharomyces pombe [Pathway:R-DDI-6796648] TP53 Regulates Transcription of DNA Repair Genes - Dictyostelium discoideum [Pathway:R-RNO-6796648] TP53 Regulates Transcription of DNA Repair Genes - Rattus norvegicus [Pathway:R-CFA-6796648] TP53 Regulates Transcription of DNA Repair Genes - Canis familiaris [Pathway:R-BTA-6796648] TP53 Regulates Transcription of DNA Repair Genes - Bos taurus [Pathway:R-SSC-6796648] TP53 Regulates Transcription of DNA Repair Genes - Sus scrofa [Pathway:R-DRE-6796648] TP53 Regulates Transcription of DNA Repair Genes - Danio rerio [Pathway:R-XTR-6796648] TP53 Regulates Transcription of DNA Repair Genes - Xenopus tropicalis [Pathway:R-GGA-6796648] TP53 Regulates Transcription of DNA Repair Genes - Gallus gallus [Pathway:R-DME-6796648] TP53 Regulates Transcription of DNA Repair Genes - Drosophila melanogaster [Pathway:R-CEL-6796648] TP53 Regulates Transcription of DNA Repair Genes - Caenorhabditis elegans
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6796648
summation	[Summation:6806638] Several DNA repair genes contain p53 response elements and t...
updateTrackers	[UpdateTracker:9777684] Update Tracker - [Pathway:6796648] TP53 Regulates Transcription of DNA Repair Genes - v69:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53
(updatedInstance)	[UpdateTracker:9777684] Update Tracker - [Pathway:6796648] TP53 Regulates Transcription of DNA Repair Genes - v69:[updateContainedRLE]

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