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Entries
TP53 Regulates Transcription of DNA Repair Genes
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authored
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
created
[InstanceEdit:6796656] Orlic-Milacic, Marija, 2015-09-04
crossReference
[DatabaseIdentifier:12325572] BioModels Database:BIOMD0000000188
[DatabaseIdentifier:12325450] BioModels Database:BIOMD0000000939
[DatabaseIdentifier:12325402] BioModels Database:BIOMD0000000940
dbId
6796648
displayName
TP53 Regulates Transcription of DNA Repair Genes
doi
10.3180/r-hsa-6796648.1
edited
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf
[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53 - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-6806412] TP53 and AP-1 bind the MSH2 promoter - Homo sapiens
[BlackBoxEvent:R-HSA-6806394] TP53 and AP-1 stimulate MSH2 expression - Homo sapiens
[Reaction:R-HSA-6806408] TP53 binds the PMS2 gene - Homo sapiens
[BlackBoxEvent:R-HSA-6806405] TP53 stimulates PMS2 expression - Homo sapiens
[Reaction:R-HSA-6806413] TP53 binds the MLH1 gene - Homo sapiens
[BlackBoxEvent:R-HSA-6806392] TP53 stimulates MLH1 expression - Homo sapiens
[Reaction:R-HSA-6806419] TP53 binds the FANCC gene - Homo sapiens
[BlackBoxEvent:R-HSA-6806425] TP53 stimulates FANCC expression - Homo sapiens
[Reaction:R-HSA-6806417] TP53 binds the DDB2 gene - Homo sapiens
[BlackBoxEvent:R-HSA-6806423] TP53 stimulates DDB2 expression - Homo sapiens
[Reaction:R-HSA-6796649] TP53 binds the CCNK gene - Homo sapiens
[BlackBoxEvent:R-HSA-6796647] TP53 stimulates CCNK expression - Homo sapiens
[Reaction:R-HSA-6797090] CCNK binds CDK12 - Homo sapiens
[Reaction:R-HSA-6797100] CCNK binds CDK13 - Homo sapiens
[Reaction:R-HSA-6797616] CCNK:CDK12 binds RNA Pol II at DNA repair genes - Homo sapiens
[Reaction:R-HSA-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Homo sapiens
[BlackBoxEvent:R-HSA-6797712] CDK12 stimulates expression of DNA repair genes - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:6806409] p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV
[LiteratureReference:6806400] Identification of a p53 response element in the promoter region of the hMSH2 gene required for expression in A2780 ovarian cancer cells
[LiteratureReference:6806407] Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements
[LiteratureReference:6806427] p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice
[LiteratureReference:6806428] p53 activates Fanconi anemia group C gene expression
[LiteratureReference:6796651] Cyclin K as a direct transcriptional target of the p53 tumor suppressor
[LiteratureReference:6797658] Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex
[LiteratureReference:6797093] The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
[LiteratureReference:6797694] The structure and substrate specificity of human Cdk12/Cyclin K
[LiteratureReference:6797674] Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex
[LiteratureReference:6797685] Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II
[LiteratureReference:8856126] RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence
[LiteratureReference:8856106] p53 responsive nucleotide excision repair gene products p48 and XPC, but not p53, localize to sites of UV-irradiation-induced DNA damage, in vivo
[LiteratureReference:8856113] A nucleotide excision repair master-switch: p53 regulated coordinate induction of global genomic repair genes
[LiteratureReference:8856105] Multiple roles of the cell cycle inhibitor p21(CDKN1A) in the DNA damage response
[LiteratureReference:8856134] p53-mediated regulation of proliferating cell nuclear antigen expression in cells exposed to ionizing radiation
[LiteratureReference:8856114] Functional evolution of the p53 regulatory network through its target response elements
[LiteratureReference:8856130] p53 coordinates base excision repair to prevent genomic instability
modified
[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name
TP53 Regulates Transcription of DNA Repair Genes
orthologousEvent
[Pathway:R-SCE-6796648] TP53 Regulates Transcription of DNA Repair Genes - Saccharomyces cerevisiae
[Pathway:R-SPO-6796648] TP53 Regulates Transcription of DNA Repair Genes - Schizosaccharomyces pombe
[Pathway:R-DDI-6796648] TP53 Regulates Transcription of DNA Repair Genes - Dictyostelium discoideum
[Pathway:R-CEL-6796648] TP53 Regulates Transcription of DNA Repair Genes - Caenorhabditis elegans
[Pathway:R-MMU-6796648] TP53 Regulates Transcription of DNA Repair Genes - Mus musculus
[Pathway:R-RNO-6796648] TP53 Regulates Transcription of DNA Repair Genes - Rattus norvegicus
[Pathway:R-CFA-6796648] TP53 Regulates Transcription of DNA Repair Genes - Canis familiaris
[Pathway:R-BTA-6796648] TP53 Regulates Transcription of DNA Repair Genes - Bos taurus
[Pathway:R-SSC-6796648] TP53 Regulates Transcription of DNA Repair Genes - Sus scrofa
[Pathway:R-DRE-6796648] TP53 Regulates Transcription of DNA Repair Genes - Danio rerio
[Pathway:R-XTR-6796648] TP53 Regulates Transcription of DNA Repair Genes - Xenopus tropicalis
[Pathway:R-GGA-6796648] TP53 Regulates Transcription of DNA Repair Genes - Gallus gallus
[Pathway:R-DME-6796648] TP53 Regulates Transcription of DNA Repair Genes - Drosophila melanogaster
releaseDate
2016-03-23
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-6796648
summation
[Summation:6806638] Several DNA repair genes contain p53 response elements and t...
Referrals
(hasEvent)
[Pathway:R-HSA-3700989] Transcriptional Regulation by TP53
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