Reactome | UVSSA:USP7 deubiquitinates ERCC6

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UVSSA:USP7 deubiquitinates ERCC6 Show undefined attributes

authored	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
catalystActivity	[CatalystActivity:6782064] cysteine-type deubiquitinase activity of Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6782070] Orlic-Milacic, Marija, 2015-06-04
dbId	6782069
displayName	UVSSA:USP7 deubiquitinates ERCC6
edited	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
eventOf	[Pathway:R-HSA-6781823] Formation of TC-NER Pre-Incision Complex - Homo sapiens
followingEvent	[Reaction:R-HSA-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-HSA-6782063] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6781981] Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair [LiteratureReference:6781971] Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair [LiteratureReference:6781993] UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair [LiteratureReference:6782030] KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR)
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	UVSSA:USP7 deubiquitinates ERCC6
orthologousEvent	[Reaction:R-MMU-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Mus musculus [Reaction:R-PFA-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Plasmodium falciparum [Reaction:R-DDI-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Dictyostelium discoideum [Reaction:R-CEL-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Caenorhabditis elegans [Reaction:R-DME-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Drosophila melanogaster [Reaction:R-GGA-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Gallus gallus [Reaction:R-XTR-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Xenopus tropicalis [Reaction:R-DRE-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Danio rerio [Reaction:R-SSC-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Sus scrofa [Reaction:R-BTA-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Bos taurus [Reaction:R-CFA-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Canis familiaris [Reaction:R-RNO-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Rattus norvegicus
output	[Complex:R-HSA-6782066] TC-NER pre-incision complex [nucleoplasm] [DefinedSet:R-HSA-68524] Ub [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6782004] Assembly of the pre-incision complex in TC-NER - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6782069
summation	[Summation:6782067] UVSSA stabilizes ERCC6 (CSB) during transcription-coupled nu...

Referrals

(hasEvent)	[Pathway:R-HSA-6781823] Formation of TC-NER Pre-Incision Complex
(precedingEvent)	[Reaction:R-HSA-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER

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