Reactome | Regulation of TLR by endogenous ligand

Schema > Pathway > Entries

created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11129124
displayName	Regulation of TLR by endogenous ligand
eventOf	[Pathway:R-PFA-168898] Toll-like Receptor Cascades - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-PFA-6805981] HMGB1 release from cells - Plasmodium falciparum [Reaction:R-PFA-6804100] HMGB1 binds LPS - Plasmodium falciparum [Reaction:R-PFA-6804099] HMGB1 binds LTP - Plasmodium falciparum
inferredFrom	[Pathway:R-HSA-5686938] Regulation of TLR by endogenous ligand - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of TLR by endogenous ligand
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-5686938
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-PFA-168898] Toll-like Receptor Cascades
(hasEncapsulatedEvent)	[Pathway:R-PFA-5620971] Pyroptosis [Pathway:R-PFA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane
(inferredTo)	[Pathway:R-HSA-5686938] Regulation of TLR by endogenous ligand

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