Reactome | SFTPA/SFTPD binds TLR4:LY96

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SFTPA/SFTPD binds TLR4:LY96 Show undefined attributes

authored	[InstanceEdit:6797423] Shamovsky, Veronica, 2015-09-12
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5432863] Shamovsky, Veronica, 2014-05-12
dbId	5432852
displayName	SFTPA/SFTPD binds TLR4:LY96
edited	[InstanceEdit:8870483] Shamovsky, Veronica, 2016-05-10
eventOf	[Pathway:R-HSA-5686938] Regulation of TLR by endogenous ligand - Homo sapiens
input	[DefinedSet:R-HSA-391108] SFTPA oligomer, SFTPD oligomer [extracellular region] [Complex:R-HSA-166050] TLR4:LY96 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5432773] Surfactant protein A directly interacts with TLR4 and MD-2 and regulates inflammatory cellular response. Importance of supratrimeric oligomerization [LiteratureReference:391070] Surfactant proteins SP-A and SP-D: structure, function and receptors [LiteratureReference:5432811] Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors [LiteratureReference:5432816] Human pulmonary surfactant protein D binds the extracellular domains of Toll-like receptors 2 and 4 through the carbohydrate recognition domain by a mechanism different from its binding to phosphatidylinositol and lipopolysaccharide
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	SFTPA/SFTPD binds TLR4:LY96 SFTPA/SFTPD binds TLR4:MD2
orthologousEvent	[Reaction:R-MMU-5432852] SFTPA/SFTPD binds TLR4:LY96 - Mus musculus [Reaction:R-GGA-5432852] SFTPA/SFTPD binds TLR4:LY96 - Gallus gallus [Reaction:R-SSC-5432852] SFTPA/SFTPD binds TLR4:LY96 - Sus scrofa [Reaction:R-BTA-5432852] SFTPA/SFTPD binds TLR4:LY96 - Bos taurus [Reaction:R-CFA-5432852] SFTPA/SFTPD binds TLR4:LY96 - Canis familiaris [Reaction:R-RNO-5432852] SFTPA/SFTPD binds TLR4:LY96 - Rattus norvegicus
output	[Complex:R-HSA-5432881] SP-A/SP-D:TLR4:MD2 [plasma membrane]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6797517] D'Eustachio, Peter, 2015-09-12 [InstanceEdit:8870806] Granucci, Francesca, Zanoni, Ivan
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5432852
summation	[Summation:6797472] The hydrophilic pulmonary surfactant proteins SP-A (SFTPA) a...

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(hasEvent)

[Pathway:R-HSA-5686938] Regulation of TLR by endogenous ligand