Reactome | HMGB1 release from cells

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HMGB1 release from cells Show undefined attributes

authored	[InstanceEdit:6797423] Shamovsky, Veronica, 2015-09-12
category	omitted
compartment	[Compartment:984] extracellular region [Compartment:7660] nucleoplasm
created	[InstanceEdit:6805948] Shamovsky, Veronica, 2015-10-21
dbId	6805981
displayName	HMGB1 release from cells
edited	[InstanceEdit:8870483] Shamovsky, Veronica, 2016-05-10
eventOf	[Pathway:R-HSA-5686938] Regulation of TLR by endogenous ligand - Homo sapiens [Pathway:R-HSA-5620971] Pyroptosis - Homo sapiens
followingEvent	[Reaction:R-HSA-6804099] HMGB1 binds LTP - Homo sapiens [Reaction:R-HSA-6804100] HMGB1 binds LPS - Homo sapiens [Reaction:R-HSA-5432825] HMGB1 binds TLR4:LY96 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-266221] HMGB1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6793809] Release of chromatin protein HMGB1 by necrotic cells triggers inflammation [LiteratureReference:6793765] The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death [LiteratureReference:6793823] The extracellular release of HMGB1 during apoptotic cell death [LiteratureReference:6793787] The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	HMGB1 release from cells
orthologousEvent	[BlackBoxEvent:R-PFA-6805981] HMGB1 release from cells - Plasmodium falciparum [BlackBoxEvent:R-SCE-6805981] HMGB1 release from cells - Saccharomyces cerevisiae [BlackBoxEvent:R-SPO-6805981] HMGB1 release from cells - Schizosaccharomyces pombe [BlackBoxEvent:R-DDI-6805981] HMGB1 release from cells - Dictyostelium discoideum [BlackBoxEvent:R-CEL-6805981] HMGB1 release from cells - Caenorhabditis elegans [BlackBoxEvent:R-DME-6805981] HMGB1 release from cells - Drosophila melanogaster [BlackBoxEvent:R-GGA-6805981] HMGB1 release from cells - Gallus gallus [BlackBoxEvent:R-XTR-6805981] HMGB1 release from cells - Xenopus tropicalis [BlackBoxEvent:R-DRE-6805981] HMGB1 release from cells - Danio rerio [BlackBoxEvent:R-SSC-6805981] HMGB1 release from cells - Sus scrofa [BlackBoxEvent:R-BTA-6805981] HMGB1 release from cells - Bos taurus [BlackBoxEvent:R-CFA-6805981] HMGB1 release from cells - Canis familiaris [BlackBoxEvent:R-RNO-6805981] HMGB1 release from cells - Rattus norvegicus [BlackBoxEvent:R-MMU-6805981] HMGB1 release from cells - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-6797422] HC23,45-HMGB1 [extracellular region]
regulatedBy	[PositiveRegulation:9710340] Positive regulation by 'GSDMD pore complex [plasma membrane]' [PositiveRegulation:9716491] Positive regulation by 'GSDME oligomer:PIP [plasma membrane]'
regulationReference	[RegulationReference:9710383] Positive regulation by 'GSDMD pore complex [plasma membrane]' Indirect regulation of HMGB1 release by gasdermin D
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6797517] D'Eustachio, Peter, 2015-09-12 [InstanceEdit:8870806] Granucci, Francesca, Zanoni, Ivan [InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6805981
summation	[Summation:6806001] High mobility group box protein 1 (HMGB1) is a ubiquitous nu...
updateTrackers	[UpdateTracker:9776331] Update Tracker - [BlackBoxEvent:6805981] HMGB1 release from cells - v76:[addRegulator, modifyText] [UpdateTracker:9782286] Update Tracker - [BlackBoxEvent:6805981] HMGB1 release from cells - v59:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776331] Update Tracker - [BlackBoxEvent:6805981] HMGB1 release from cells - v76:[addRegulator, modifyText] [UpdateTracker:9782286] Update Tracker - [BlackBoxEvent:6805981] HMGB1 release from cells - v59:[modifyText]
(hasEvent)	[Pathway:R-HSA-5686938] Regulation of TLR by endogenous ligand [Pathway:R-HSA-5620971] Pyroptosis
(precedingEvent)	[Reaction:R-HSA-6804099] HMGB1 binds LTP [Reaction:R-HSA-6804100] HMGB1 binds LPS [Reaction:R-HSA-5432825] HMGB1 binds TLR4:LY96

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