Reactome | oxLDL:CD36 binds TLR4:TLR6

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oxLDL:CD36 binds TLR4:TLR6 Show undefined attributes

authored	[InstanceEdit:8869700] Shamovsky, Veronica, 2016-05-06
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8869700] Shamovsky, Veronica, 2016-05-06
dbId	8869667
displayName	oxLDL:CD36 binds TLR4:TLR6
edited	[InstanceEdit:8870483] Shamovsky, Veronica, 2016-05-10
eventOf	[Pathway:R-HSA-5686938] Regulation of TLR by endogenous ligand - Homo sapiens
input	[Complex:R-HSA-8869680] oxLDL:CD36 [plasma membrane] [Complex:R-HSA-8869699] TLR4:TLR6 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8869665] CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer [LiteratureReference:2187087] CD36 is a receptor for oxidized low density lipoprotein
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	oxLDL:CD36 binds TLR4:TLR6
orthologousEvent	[Reaction:R-MMU-8869667] oxLDL:CD36 binds TLR4:TLR6 - Mus musculus [Reaction:R-GGA-8869667] oxLDL:CD36 binds TLR4:TLR6 - Gallus gallus [Reaction:R-SSC-8869667] oxLDL:CD36 binds TLR4:TLR6 - Sus scrofa [Reaction:R-BTA-8869667] oxLDL:CD36 binds TLR4:TLR6 - Bos taurus [Reaction:R-RNO-8869667] oxLDL:CD36 binds TLR4:TLR6 - Rattus norvegicus
output	[Complex:R-HSA-8869674] TLR4:TLR6:CD36:oxLDL [plasma membrane]
precedingEvent	[Reaction:R-HSA-2187264] Platelet glycoprotein IV (CD36) binds ligands - Homo sapiens
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870806] Granucci, Francesca, Zanoni, Ivan
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8869667
summation	[Summation:8870528] Oxidized low-density lipoprotein (oxLDL) and amyloid-beta se...

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[Pathway:R-HSA-5686938] Regulation of TLR by endogenous ligand

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