Reactome | SFTPA/SFTPD binds TLR2:TLR1

Schema > Reaction > Entries

SFTPA/SFTPD binds TLR2:TLR1 Show undefined attributes

authored	[InstanceEdit:6797423] Shamovsky, Veronica, 2015-09-12
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5432863] Shamovsky, Veronica, 2014-05-12
dbId	5432814
displayName	SFTPA/SFTPD binds TLR2:TLR1
edited	[InstanceEdit:8870483] Shamovsky, Veronica, 2016-05-10
eventOf	[Pathway:R-HSA-5686938] Regulation of TLR by endogenous ligand - Homo sapiens
input	[DefinedSet:R-HSA-391108] SFTPA oligomer, SFTPD oligomer [extracellular region] [Complex:R-HSA-168946] TLR1:TLR2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:391070] Surfactant proteins SP-A and SP-D: structure, function and receptors [LiteratureReference:5432816] Human pulmonary surfactant protein D binds the extracellular domains of Toll-like receptors 2 and 4 through the carbohydrate recognition domain by a mechanism different from its binding to phosphatidylinositol and lipopolysaccharide [LiteratureReference:5432819] Surfactant protein A inhibits peptidoglycan-induced tumor necrosis factor-alpha secretion in U937 cells and alveolar macrophages by direct interaction with toll-like receptor 2 [LiteratureReference:5432732] Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	SFTPA/SFTPD binds TLR2:TLR1
orthologousEvent	[Reaction:R-MMU-5432814] SFTPA/SFTPD binds TLR2:TLR1 - Mus musculus [Reaction:R-DME-5432814] SFTPA/SFTPD binds TLR2:TLR1 - Drosophila melanogaster [Reaction:R-GGA-5432814] SFTPA/SFTPD binds TLR2:TLR1 - Gallus gallus [Reaction:R-DRE-5432814] SFTPA/SFTPD binds TLR2:TLR1 - Danio rerio [Reaction:R-SSC-5432814] SFTPA/SFTPD binds TLR2:TLR1 - Sus scrofa [Reaction:R-CFA-5432814] SFTPA/SFTPD binds TLR2:TLR1 - Canis familiaris [Reaction:R-RNO-5432814] SFTPA/SFTPD binds TLR2:TLR1 - Rattus norvegicus
output	[Complex:R-HSA-5432872] SFTPA/SFTPD:TLR2:TLR1 [plasma membrane]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6797517] D'Eustachio, Peter, 2015-09-12 [InstanceEdit:8870806] Granucci, Francesca, Zanoni, Ivan
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5432814
summation	[Summation:6800861] The lung surfactant proteins SP-A (also known as SFTPA) and ...

Referrals

(hasEvent)

[Pathway:R-HSA-5686938] Regulation of TLR by endogenous ligand

Cite Us!