Reactome | MAP3K8 (TPL2)-dependent MAPK1/3 activation

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MAP3K8 (TPL2)-dependent MAPK1/3 activation Show undefined attributes

authored	[InstanceEdit:5692834] Shamovsky, Veronica, 2015-05-12
created	[InstanceEdit:5684256] Shamovsky, Veronica, 2015-03-20
crossReference	[DatabaseIdentifier:12819573] BioModels Database:BIOMD0000000243 [DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883
dbId	5684264
displayName	MAP3K8 (TPL2)-dependent MAPK1/3 activation
doi	10.3180/r-hsa-5684264.1
edited	[InstanceEdit:6792550] Shamovsky, Veronica, 2015-08-25
eventOf	[Pathway:R-HSA-450294] MAP kinase activation - Homo sapiens [Pathway:R-HSA-9020702] Interleukin-1 signaling - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-451634] NFKB p105, TPL2 (COT) and ABIN2 form a stable complex - Homo sapiens [Reaction:R-HSA-5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - Homo sapiens [Reaction:R-HSA-5684261] MAP3K8 is phosphorylated - Homo sapiens [Reaction:R-HSA-5684267] IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex - Homo sapiens [Reaction:R-HSA-5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 - Homo sapiens [Reaction:R-HSA-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Homo sapiens [BlackBoxEvent:R-HSA-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Homo sapiens [Reaction:R-HSA-451649] TPL2 phosphorylates MEK1, SEK1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:5687816] Coordinate regulation of TPL-2 and NF-?B signaling in macrophages by NF-?B1 p105 [LiteratureReference:5684203] Regulation and function of TPL-2, an I?B kinase-regulated MAP kinase kinase kinase [Book:6792513] The Role of Tpl2 Protein Kinase in Carcinogenesis and Inflammation Da Silva Xavier, Gabriela Advances in Protein Kinases 978-953-51-0633-3
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	MAP3K8 (TPL2)-dependent MAPK1/3 activation
orthologousEvent	[Pathway:R-GGA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Gallus gallus [Pathway:R-XTR-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Xenopus tropicalis [Pathway:R-DRE-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Danio rerio [Pathway:R-SSC-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Sus scrofa [Pathway:R-BTA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Bos taurus [Pathway:R-RNO-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Rattus norvegicus [Pathway:R-MMU-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Mus musculus
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5688083] Jupe, Steve, 2015-04-14 [InstanceEdit:6791477] DeCicco-Skinner, Kathleen L., 2015-08-20
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5684264
summation	[Summation:5684249] Tumor progression locus-2 (TPL2, also known as COT and MAP3K...
updateTrackers	[UpdateTracker:9774681] Update Tracker - [Pathway:5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - v81:[updateContainedRLE] [UpdateTracker:9774965] Update Tracker - [Pathway:5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - v80:[updateContainedRLE] [UpdateTracker:9779858] Update Tracker - [Pathway:5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - v64:[updateContainedRLE] [UpdateTracker:9864061] Update Tracker - [Pathway:5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - v88:[updateContainedRLE] [UpdateTracker:9775989] Update Tracker - [Pathway:5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - v78:[updateContainedRLE] [UpdateTracker:9782417] Update Tracker - [Pathway:5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - v59:[modifyText]

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