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Entries
MAP3K8 (TPL2)-dependent MAPK1/3 activation
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authored
[InstanceEdit:5692834] Shamovsky, Veronica, 2015-05-12
created
[InstanceEdit:5684256] Shamovsky, Veronica, 2015-03-20
crossReference
[DatabaseIdentifier:12325540] BioModels Database:BIOMD0000000243
[DatabaseIdentifier:12325418] BioModels Database:BIOMD0000000407
[DatabaseIdentifier:12325346] BioModels Database:BIOMD0000000883
dbId
5684264
displayName
MAP3K8 (TPL2)-dependent MAPK1/3 activation
doi
10.3180/r-hsa-5684264.1
edited
[InstanceEdit:6792550] Shamovsky, Veronica, 2015-08-25
eventOf
[Pathway:R-HSA-450294] MAP kinase activation - Homo sapiens
[Pathway:R-HSA-9020702] Interleukin-1 signaling - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-451634] NFKB p105, TPL2 (COT) and ABIN2 form a stable complex - Homo sapiens
[Reaction:R-HSA-5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - Homo sapiens
[Reaction:R-HSA-5684261] MAP3K8 is phosphorylated - Homo sapiens
[Reaction:R-HSA-5684267] IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex - Homo sapiens
[Reaction:R-HSA-5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 - Homo sapiens
[Reaction:R-HSA-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Homo sapiens
[BlackBoxEvent:R-HSA-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Homo sapiens
[Reaction:R-HSA-451649] TPL2 phosphorylates MEK1, SEK1 - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5687816] Coordinate regulation of TPL-2 and NF-?B signaling in macrophages by NF-?B1 p105
[LiteratureReference:5684203] Regulation and function of TPL-2, an I?B kinase-regulated MAP kinase kinase kinase
[Book:6792513] The Role of Tpl2 Protein Kinase in Carcinogenesis and Inflammation Da Silva Xavier, Gabriela Advances in Protein Kinases 978-953-51-0633-3
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
MAP3K8 (TPL2)-dependent MAPK1/3 activation
orthologousEvent
[Pathway:R-GGA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Gallus gallus
[Pathway:R-XTR-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Xenopus tropicalis
[Pathway:R-SSC-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Sus scrofa
[Pathway:R-BTA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Bos taurus
[Pathway:R-CFA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Canis familiaris
[Pathway:R-MMU-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Mus musculus
releaseDate
2015-09-22
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5688083] Jupe, Steve, 2015-04-14
[InstanceEdit:6791477] DeCicco-Skinner, Kathleen L., 2015-08-20
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5684264
summation
[Summation:5684249] Tumor progression locus-2 (TPL2, also known as COT and MAP3K...
Referrals
(hasEvent)
[Pathway:R-HSA-9020702] Interleukin-1 signaling
[Pathway:R-HSA-450294] MAP kinase activation
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