Reactome | 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105

Schema > BlackBoxEvent > Entries

3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 Show undefined attributes

authored	[InstanceEdit:5692834] Shamovsky, Veronica, 2015-05-12
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5684256] Shamovsky, Veronica, 2015-03-20
dbId	5684273
displayName	3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105
edited	[InstanceEdit:6792550] Shamovsky, Veronica, 2015-08-25
eventOf	[Pathway:R-HSA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Homo sapiens
followingEvent	[Reaction:R-HSA-451649] TPL2 phosphorylates MEK1, SEK1 - Homo sapiens
input	[Complex:R-HSA-5684242] 3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5684243] I?B kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400 [LiteratureReference:451627] NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity [LiteratureReference:451635] NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105
orthologousEvent	[BlackBoxEvent:R-GGA-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Gallus gallus [BlackBoxEvent:R-XTR-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Xenopus tropicalis [BlackBoxEvent:R-DRE-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Danio rerio [BlackBoxEvent:R-SSC-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Sus scrofa [BlackBoxEvent:R-BTA-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Bos taurus [BlackBoxEvent:R-RNO-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Rattus norvegicus [BlackBoxEvent:R-MMU-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-5684259] p-S400,T290-MAP3K8 [cytosol] [EntityWithAccessionedSequence:R-HSA-451661] TNIP2 [cytosol] 9 × [DefinedSet:R-HSA-113595] Ub [cytosol]
precedingEvent	[Reaction:R-HSA-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5688083] Jupe, Steve, 2015-04-14 [InstanceEdit:6791477] DeCicco-Skinner, Kathleen L., 2015-08-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5684273
summation	[Summation:5687814] IKBKB-induced proteolysis of NFkB p105 to p50 releases MAP3K...

Referrals

(hasEvent)	[Pathway:R-HSA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation
(precedingEvent)	[Reaction:R-HSA-451649] TPL2 phosphorylates MEK1, SEK1