Reactome | SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2

Schema > Reaction > Entries

SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 Show undefined attributes

authored	[InstanceEdit:5692834] Shamovsky, Veronica, 2015-05-12
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5684256] Shamovsky, Veronica, 2015-03-20
dbId	5684248
deleted	[Deleted:8861901] Deletion of instance: 451609
displayName	SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2
edited	[InstanceEdit:6792550] Shamovsky, Veronica, 2015-08-25
eventOf	[Pathway:R-HSA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Homo sapiens
followingEvent	[Reaction:R-HSA-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Homo sapiens
input	[DefinedSet:R-HSA-1168601] (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] [Complex:R-HSA-5684268] p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:451620] Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing [LiteratureReference:451595] betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932 [LiteratureReference:5684257] Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2
orthologousEvent	[Reaction:R-DRE-5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 - Danio rerio [Reaction:R-RNO-5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 - Rattus norvegicus [Reaction:R-MMU-5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 - Mus musculus
output	[Complex:R-HSA-5684270] SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol]
precedingEvent	[Reaction:R-HSA-5684267] IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex - Homo sapiens [Reaction:R-HSA-5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - Homo sapiens [Reaction:R-HSA-5684261] MAP3K8 is phosphorylated - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5688083] Jupe, Steve, 2015-04-14 [InstanceEdit:6791477] DeCicco-Skinner, Kathleen L., 2015-08-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5684248
summation	[Summation:451606] IKK-mediated NFkB p105 phosphorylation generates a binding s...
systematicName	BTRC:CUL1:SKP1 or FBXW11:CUL1:SKP1 binds p-S927, S-932-NFKB1(1-968):MAP3K8:TNIP2

Referrals

(replacementInstances)	[Deleted:8861901] Deletion of instance: 451609
(hasEvent)	[Pathway:R-HSA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation
(precedingEvent)	[Reaction:R-HSA-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2

Cite Us!