Reactome | IKBKB phosphorylates TPL2 (MAP3K8) at Ser400

Schema > Reaction > Entries

IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 Show undefined attributes

authored	[InstanceEdit:5692834] Shamovsky, Veronica, 2015-05-12
catalystActivity	[CatalystActivity:9773797] IkappaB kinase activity of CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5684256] Shamovsky, Veronica, 2015-03-20
dbId	5684275
displayName	IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
edited	[InstanceEdit:6792550] Shamovsky, Veronica, 2015-08-25
eventOf	[Pathway:R-HSA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Homo sapiens
followingEvent	[Reaction:R-HSA-5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-451638] NFKB1:MAP3K8:TNIP2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5684243] I?B kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400 [LiteratureReference:5684245] Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
orthologousEvent	[Reaction:R-GGA-5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - Gallus gallus [Reaction:R-XTR-5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - Xenopus tropicalis [Reaction:R-DRE-5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - Danio rerio [Reaction:R-SSC-5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - Sus scrofa [Reaction:R-BTA-5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - Bos taurus [Reaction:R-RNO-5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - Rattus norvegicus [Reaction:R-MMU-5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-5687880] NFKB1:p-S400-MAP3K8:TNIP2 [cytosol]
precedingEvent	[Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex - Homo sapiens [Reaction:R-HSA-451634] NFKB p105, TPL2 (COT) and ABIN2 form a stable complex - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5688083] Jupe, Steve, 2015-04-14 [InstanceEdit:6791477] DeCicco-Skinner, Kathleen L., 2015-08-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5684275
summation	[Summation:5684244] The activity of tumor progression locus-2 (TPL2, also known ...
systematicName	IKBKB phosphorylates MAP3K8
updateTrackers	[UpdateTracker:9864136] Update Tracker - [Reaction:5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - v88:[modifyText, removeLiteratureReference] [UpdateTracker:9774723] Update Tracker - [Reaction:5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - v81:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9864136] Update Tracker - [Reaction:5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - v88:[modifyText, removeLiteratureReference] [UpdateTracker:9774723] Update Tracker - [Reaction:5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - v81:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation
(precedingEvent)	[Reaction:R-HSA-5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2