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Schema
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Reaction
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Entries
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2
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authored
[InstanceEdit:5692834] Shamovsky, Veronica, 2015-05-12
catalystActivity
[CatalystActivity:5687862] ubiquitin-protein transferase activity of SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol]
catalystActivityReference
[CatalystActivityReference:9643613] ubiquitin-protein transferase activity of SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:5684256] Shamovsky, Veronica, 2015-03-20
dbId
5684250
deleted
[Deleted:8861900] Deletion of instance: 451617
displayName
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2
edited
[InstanceEdit:6792550] Shamovsky, Veronica, 2015-08-25
eventOf
[Pathway:R-HSA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 - Homo sapiens
input
[Complex:R-HSA-5684270] SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol]
9 ×
[DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:451620] Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing
[LiteratureReference:9765567] Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1
maxDepth
1
modified
[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2
orthologousEvent
[Reaction:R-DRE-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Danio rerio
[Reaction:R-RNO-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Rattus norvegicus
[Reaction:R-MMU-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Mus musculus
output
[DefinedSet:R-HSA-1168601] (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol]
[Complex:R-HSA-5684242] 3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
precedingEvent
[Reaction:R-HSA-5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 - Homo sapiens
releaseDate
2015-09-22
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5688083] Jupe, Steve, 2015-04-14
[InstanceEdit:6791477] DeCicco-Skinner, Kathleen L., 2015-08-20
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5684250
summation
[Summation:451622] Beta-TrCP ubiquitinates p105 at several lysine residues with...
updateTrackers
[UpdateTracker:9779763] Update Tracker - [Reaction:5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - v64:[addInput]
[UpdateTracker:9774871] Update Tracker - [Reaction:5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - v80:[addLiteratureReference]
Referrals
(updatedInstance)
[UpdateTracker:9779763] Update Tracker - [Reaction:5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - v64:[addInput]
[UpdateTracker:9774871] Update Tracker - [Reaction:5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - v80:[addLiteratureReference]
(replacementInstances)
[Deleted:8861900] Deletion of instance: 451617
(hasEvent)
[Pathway:R-HSA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation
(precedingEvent)
[BlackBoxEvent:R-HSA-5684273] 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105
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