Reactome | MAP3K8 is phosphorylated

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MAP3K8 is phosphorylated Show undefined attributes

authored	[InstanceEdit:5692834] Shamovsky, Veronica, 2015-05-12
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5684256] Shamovsky, Veronica, 2015-03-20
dbId	5684261
displayName	MAP3K8 is phosphorylated
edited	[InstanceEdit:6792550] Shamovsky, Veronica, 2015-08-25
eventOf	[Pathway:R-HSA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Homo sapiens
followingEvent	[Reaction:R-HSA-5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-451638] NFKB1:MAP3K8:TNIP2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5684245] Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62 [LiteratureReference:5687829] Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	MAP3K8 is phosphorylated TPL2 (MAP3K8) is phosphorylated at T290
orthologousEvent	[Reaction:R-GGA-5684261] MAP3K8 is phosphorylated - Gallus gallus [Reaction:R-XTR-5684261] MAP3K8 is phosphorylated - Xenopus tropicalis [Reaction:R-DRE-5684261] MAP3K8 is phosphorylated - Danio rerio [Reaction:R-SSC-5684261] MAP3K8 is phosphorylated - Sus scrofa [Reaction:R-BTA-5684261] MAP3K8 is phosphorylated - Bos taurus [Reaction:R-RNO-5684261] MAP3K8 is phosphorylated - Rattus norvegicus [Reaction:R-MMU-5684261] MAP3K8 is phosphorylated - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-5684265] NFKB1:p-T290-MAP3K8:TNIP2 [cytosol]
precedingEvent	[Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5688083] Jupe, Steve, 2015-04-14 [InstanceEdit:6791477] DeCicco-Skinner, Kathleen L., 2015-08-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5684261
summation	[Summation:5684251] The activity of tumor progression locus-2 (TPL2, also known ...
systematicName	IKBKB phosphorylates MAP3K8
updateTrackers	[UpdateTracker:9863960] Update Tracker - [Reaction:5684261] MAP3K8 is phosphorylated - v88:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9863960] Update Tracker - [Reaction:5684261] MAP3K8 is phosphorylated - v88:[modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation
(precedingEvent)	[Reaction:R-HSA-5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2

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