SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2

Stable Identifier
R-HSA-5684248
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2
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IKK-mediated NFkB p105 phosphorylation generates a binding site for betaTrCP, the receptor subunit of the SCF-type beta-TrCP ubiquitin E3 ligase complex.
Literature References
PubMed ID Title Journal Year
12482991 betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932

Lang, V, Janzen, J, Fischer, GZ, Soneji, Y, Beinke, S, Salmeron, A, Allen, H, Hay, RT, Ben-Neriah, Y, Ley, SC

Mol Cell Biol 2003
11158290 Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha

Heissmeyer, V, Krappmann, D, Hatada, EN, Scheidereit, C

Mol. Cell. Biol. 2001
14673179 Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing

Cohen, S, Achbert-Weiner, H, Ciechanover, A

Mol Cell Biol 2004
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Orthologous Events
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Gallus gallus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)
Authored
Shamovsky, V  (2015-05-13)
Reviewed
Jupe, S  (2015-04-14)
DeCicco-Skinner, KL  (2015-08-21)
Created
Shamovsky, V  (2015-03-20)
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