Reactome | SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2

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SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10060760
displayName	SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2
eventOf	[Pathway:R-MMU-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Mus musculus
inferredFrom	[Reaction:R-HSA-5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 - Homo sapiens
input	[Complex:R-MMU-1168592] CUL1:FBXW11:SKP1 [cytosol] [Complex:R-MMU-5684268] p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2
output	[Complex:R-MMU-5684270] SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol]
precedingEvent	[Reaction:R-MMU-5684267] IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex - Mus musculus [Reaction:R-MMU-5684275] IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 - Mus musculus [Reaction:R-MMU-5684261] MAP3K8 is phosphorylated - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5684248
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5684264] MAP3K8 (TPL2)-dependent MAPK1/3 activation
(precedingEvent)	[Reaction:R-MMU-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2
(inferredTo)	[Reaction:R-HSA-5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2