Reactome | p-2S MAP2K homo/heterodimers [cytosol]

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p-2S MAP2K homo/heterodimers [cytosol] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-5672734] RAF activating kinases [plasma membrane] - Homo sapiens
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9656185] activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] - Homo sapiens [Complex:R-HSA-6802711] p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] - Homo sapiens [Complex:R-HSA-6802710] p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5674366] IL17RD binds p-2S MAP2Ks and MAPKs - Homo sapiens
created	[InstanceEdit:5672722] Rothfels, Karen, 2015-02-05
dbId	5672721
displayName	p-2S MAP2K homo/heterodimers [cytosol]
hasMember	[Complex:R-HSA-5672705] p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] - Homo sapiens [Complex:R-HSA-5672703] p-S218,S222 MAP2K1 dimer [cytosol] - Homo sapiens [Complex:R-HSA-5672701] p-S222,S226 MAP2K2 dimer [cytosol] - Homo sapiens
inDisease	false
inferredTo	[DefinedSet:R-MMU-5672721] p-2S MAP2K homo/heterodimers [cytosol] - Mus musculus [DefinedSet:R-RNO-5672721] p-2S MAP2K homo/heterodimers [cytosol] - Rattus norvegicus [Complex:R-CFA-5672701] p-S222,S226 MAP2K2 dimer [cytosol] - Canis familiaris [Complex:R-BTA-5672703] p-S218,S222 MAP2K1 dimer [cytosol] - Bos taurus [Complex:R-SSC-5672701] p-S222,S226 MAP2K2 dimer [cytosol] - Sus scrofa [DefinedSet:R-DRE-5672721] p-2S MAP2K homo/heterodimers [cytosol] - Danio rerio [GenomeEncodedEntity:R-GGA-5672721] Ghost homologue of p-2S MAP2K homo/heterodimers [cytosol] - Gallus gallus [DefinedSet:R-DME-5672721] p-2S MAP2K homo/heterodimers [cytosol] - Drosophila melanogaster [DefinedSet:R-CEL-5672721] p-2S MAP2K homo/heterodimers [cytosol] - Caenorhabditis elegans [DefinedSet:R-DDI-5672721] p-2S MAP2K homo/heterodimers [cytosol] - Dictyostelium discoideum
maxDepth	3
name	p-2S MAP2K homo/heterodimers
producedByEvent	[Reaction:R-HSA-6803234] Dissociation of paradoxically activated RAS:BRAF complexes - Homo sapiens [Reaction:R-HSA-6803230] Dissociation of moderate activity BRAF complexes - Homo sapiens [Reaction:R-HSA-6803227] Dissociation of high activity BRAF complexes - Homo sapiens [Reaction:R-HSA-6803233] Dissociation of oncogenic RAS:RAF complex - Homo sapiens [BlackBoxEvent:R-HSA-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs - Homo sapiens [Reaction:R-HSA-6802932] Dissociation of BRAF/RAF fusion complex - Homo sapiens [Reaction:R-HSA-9656209] Dissociation of RAS:RAF1 mutant complex - Homo sapiens [Reaction:R-HSA-5672980] Dissociation of RAS:RAF complex - Homo sapiens
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-5672721

Referrals

(output)	[Reaction:R-HSA-6802932] Dissociation of BRAF/RAF fusion complex [Reaction:R-HSA-9656209] Dissociation of RAS:RAF1 mutant complex [Reaction:R-HSA-6803234] Dissociation of paradoxically activated RAS:BRAF complexes [Reaction:R-HSA-6803230] Dissociation of moderate activity BRAF complexes [Reaction:R-HSA-6803227] Dissociation of high activity BRAF complexes [Reaction:R-HSA-6803233] Dissociation of oncogenic RAS:RAF complex [BlackBoxEvent:R-HSA-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs [Reaction:R-HSA-5672980] Dissociation of RAS:RAF complex
(hasComponent)	[Complex:R-HSA-6802711] p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] [Complex:R-HSA-6802710] p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] [Complex:R-HSA-9656182] activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] [Complex:R-HSA-9656185] activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] [Complex:R-HSA-6802637] RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] [Complex:R-HSA-6802625] RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] [Complex:R-HSA-6802648] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] [Complex:R-HSA-6802647] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] [Complex:R-HSA-6802666] high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] [Complex:R-HSA-6802664] high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] [Complex:R-HSA-6802669] mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] [Complex:R-HSA-6802672] mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] [Complex:R-HSA-5674131] WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] [Complex:R-HSA-5674362] IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] [Complex:R-HSA-5674360] IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] [Complex:R-HSA-9610136] RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] [Complex:R-HSA-9610140] RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] [Complex:R-HSA-5672723] activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] [Complex:R-HSA-5672724] activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]
(activeUnit)	[CatalystActivity:9656191] protein serine/threonine kinase activity of activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] [CatalystActivity:5674372] protein serine/threonine/tyrosine kinase activity of IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] [CatalystActivity:5672974] protein serine/threonine kinase activity of activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
(input)	[Reaction:R-HSA-5674366] IL17RD binds p-2S MAP2Ks and MAPKs
(hasCandidate)	[CandidateSet:R-HSA-5672734] RAF activating kinases [plasma membrane]

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