Reactome | IL17RD binds p-2S MAP2Ks and MAPKs

Schema > Reaction > Entries

IL17RD binds p-2S MAP2Ks and MAPKs Show undefined attributes

authored	[InstanceEdit:5674147] Rothfels, Karen, 2015-02-10
category	binding
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:5674363] Rothfels, Karen, 2015-02-11
dbId	5674366
deleted	[Deleted:6799074] Deletion of instance: 1268203 [Deleted:6799076] Deletion of instance: 1268214
displayName	IL17RD binds p-2S MAP2Ks and MAPKs
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5674135] MAP2K and MAPK activation - Homo sapiens
followingEvent	[Reaction:R-HSA-5674373] MAP2Ks phosphorylate MAPK at the Golgi membrane - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5674277] IL17RD [Golgi membrane] [DefinedSet:R-HSA-169291] MAPKs [cytosol] [DefinedSet:R-HSA-5672721] p-2S MAP2K homo/heterodimers [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5674365] Identification of Sef, a novel modulator of FGF signalling [LiteratureReference:5674368] Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling [LiteratureReference:1268087] Sef is a spatial regulator for Ras/MAP kinase signaling [LiteratureReference:5674364] Sef: a MEK/ERK catcher on the Golgi [LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	IL17RD binds p-2S MAP2Ks and MAPKs
orthologousEvent	[Reaction:R-CEL-5674366] IL17RD binds p-2S MAP2Ks and MAPKs - Caenorhabditis elegans [Reaction:R-DRE-5674366] IL17RD binds p-2S MAP2Ks and MAPKs - Danio rerio [Reaction:R-SSC-5674366] IL17RD binds p-2S MAP2Ks and MAPKs - Sus scrofa [Reaction:R-BTA-5674366] IL17RD binds p-2S MAP2Ks and MAPKs - Bos taurus [Reaction:R-CFA-5674366] IL17RD binds p-2S MAP2Ks and MAPKs - Canis familiaris [Reaction:R-RNO-5674366] IL17RD binds p-2S MAP2Ks and MAPKs - Rattus norvegicus [Reaction:R-MMU-5674366] IL17RD binds p-2S MAP2Ks and MAPKs - Mus musculus
output	[Complex:R-HSA-5674360] IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane]
precedingEvent	[Reaction:R-HSA-5672980] Dissociation of RAS:RAF complex - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5674366
summation	[Summation:5674367] IL17RD, also known as SEF (similar expression to FGF), was i...

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(replacementInstances)	[Deleted:6799074] Deletion of instance: 1268203 [Deleted:6799076] Deletion of instance: 1268214
(hasEvent)	[Pathway:R-HSA-5674135] MAP2K and MAPK activation
(precedingEvent)	[Reaction:R-HSA-5674373] MAP2Ks phosphorylate MAPK at the Golgi membrane