Reactome | Dissociation of RAS:RAF1 mutant complex

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Dissociation of RAS:RAF1 mutant complex Show undefined attributes

authored	[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
category	dissociation
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9656210] Rothfels, Karen, 2019-07-27
crossReference	[DatabaseIdentifier:12020787] Mondo:0005045
dbId	9656209
disease	[Disease:9651116] Costello syndrome [Disease:9651118] LEOPARD syndrome [Disease:6802289] Noonan syndrome [Disease:1500689] cancer [Disease:6788675] hypertrophic cardiomyopathy
displayName	Dissociation of RAS:RAF1 mutant complex
edited	[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
entityFunctionalStatus	[EntityFunctionalStatus:9656200] gain_of_function of activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]
eventOf	[Pathway:R-HSA-9656223] Signaling by RAF1 mutants - Homo sapiens
input	[Complex:R-HSA-9656185] activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks [LiteratureReference:5672144] "RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of RAS:RAF1 mutant complex
normalReaction	[Reaction:R-HSA-5672980] Dissociation of RAS:RAF complex
output	[DefinedSet:R-HSA-5672721] p-2S MAP2K homo/heterodimers [cytosol] [DefinedSet:R-HSA-169289] p-T,Y MAPKs [cytosol] [Complex:R-HSA-9656176] p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] [CandidateSet:R-HSA-5672717] RAF/MAPK scaffolds [cytosol]
precedingEvent	[Reaction:R-HSA-9656214] MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9656209
summation	[Summation:9655943] After phosphorylation of MAPKs by complexes containing RAF1 ...

Referrals

(hasEvent)

[Pathway:R-HSA-9656223] Signaling by RAF1 mutants

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