Reactome | Dissociation of oncogenic RAS:RAF complex

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Dissociation of oncogenic RAS:RAF complex Show undefined attributes

authored	[InstanceEdit:6802811] Rothfels, Karen, 2015-08-10
category	dissociation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6803232] Rothfels, Karen, 2015-10-05
crossReference	[DatabaseIdentifier:12020778] Mondo:0018997
dbId	6803233
disease	[Disease:1500689] cancer [Disease:6802289] Noonan syndrome
displayName	Dissociation of oncogenic RAS:RAF complex
edited	[InstanceEdit:6802811] Rothfels, Karen, 2015-08-10
entityFunctionalStatus	[EntityFunctionalStatus:6803231] gain_of_function of mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]
eventOf	[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants - Homo sapiens
input	[Complex:R-HSA-6802672] mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling [LiteratureReference:6799045] Dragging ras back in the ring
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of oncogenic RAS:RAF complex
normalReaction	[Reaction:R-HSA-5672980] Dissociation of RAS:RAF complex
output	[DefinedSet:R-HSA-5672721] p-2S MAP2K homo/heterodimers [cytosol] [DefinedSet:R-HSA-169289] p-T,Y MAPKs [cytosol] [CandidateSet:R-HSA-5672717] RAF/MAPK scaffolds [cytosol] [Complex:R-HSA-6802617] RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-6802922] Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6803233
summation	[Summation:6803224] After phosphorylation by MAP2Ks, the scaffolded kinase compl...

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(hasEvent)

[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants

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