Reactome | activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]

Schema > Complex > Entries

activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-9656209] Dissociation of RAS:RAF1 mutant complex - Homo sapiens
created	[InstanceEdit:9656184] Rothfels, Karen, 2019-07-27
crossReference	[DatabaseIdentifier:12020787] Mondo:0005045
dbId	9656185
disease	[Disease:9651116] Costello syndrome [Disease:9651118] LEOPARD syndrome [Disease:6802289] Noonan syndrome [Disease:1500689] cancer [Disease:6788675] hypertrophic cardiomyopathy
displayName	activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]
hasComponent	[DefinedSet:R-HSA-5672721] p-2S MAP2K homo/heterodimers [cytosol] [DefinedSet:R-HSA-169289] p-T,Y MAPKs [cytosol] [Complex:R-HSA-9656176] p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] [CandidateSet:R-HSA-5672717] RAF/MAPK scaffolds [cytosol]
inDisease	true
includedLocation	[Compartment:70101] cytosol
isChimeric	false
maxDepth	11
modified	[InstanceEdit:9665048] Rothfels, Karen, 2019-10-28
name	activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex
producedByEvent	[Reaction:R-HSA-9656214] MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9656185
updateTrackers	[UpdateTracker:9919647] Update Tracker - [Complex:9656185] activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] - v90:[updateContainedComponent] [UpdateTracker:9928680] Update Tracker - [Complex:9656185] activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] - v91:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9919647] Update Tracker - [Complex:9656185] activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] - v90:[updateContainedComponent] [UpdateTracker:9928680] Update Tracker - [Complex:9656185] activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] - v91:[updateContainedComponent]
(output)	[Reaction:R-HSA-9656214] MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants
(input)	[Reaction:R-HSA-9656209] Dissociation of RAS:RAF1 mutant complex
(diseaseEntity)	[EntityFunctionalStatus:9656200] gain_of_function of activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]

© 2026 Reactome

Cite Us!